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Pulmonary Vasculature Redox Signaling in Health and Disease

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Cover of 'Pulmonary Vasculature Redox Signaling in Health and Disease'

Table of Contents

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    Book Overview
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    Chapter 1 Adventitial Fibroblast Nox4 Expression and ROS Signaling in Pulmonary Arterial Hypertension
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    Chapter 2 Role of Transcription Factors in Pulmonary Artery Smooth Muscle Cells: An Important Link to Hypoxic Pulmonary Hypertension
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    Chapter 3 Molecular Basis of Nitrative Stress in the Pathogenesis of Pulmonary Hypertension
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    Chapter 4 Pentose Shunt, Glucose-6-Phosphate Dehydrogenase, NADPH Redox, and Stem Cells in Pulmonary Hypertension
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    Chapter 5 Redox Regulation of the Superoxide Dismutases SOD3 and SOD2 in the Pulmonary Circulation
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    Chapter 6 A Brief Overview of Nitric Oxide and Reactive Oxygen Species Signaling in Hypoxia-Induced Pulmonary Hypertension
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    Chapter 7 Altered Redox Balance in the Development of Chronic Hypoxia-induced Pulmonary Hypertension
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    Chapter 8 ROS Signaling in the Pathogenesis of Acute Lung Injury (ALI) and Acute Respiratory Distress Syndrome (ARDS)
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    Chapter 9 Redox-Dependent Calpain Signaling in Airway and Pulmonary Vascular Remodeling in COPD
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    Chapter 10 Natural Antioxidants as Potential Therapy, and a Promising Role for Melatonin Against Pulmonary Hypertension
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    Chapter 11 Effects of Hyperoxia on the Developing Airway and Pulmonary Vasculature
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    Chapter 12 Lung Ischaemia–Reperfusion Injury: The Role of Reactive Oxygen Species
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    Chapter 13 Redox Mechanisms Influencing cGMP Signaling in Pulmonary Vascular Physiology and Pathophysiology
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    Chapter 14 Metabolic Reprogramming and Redox Signaling in Pulmonary Hypertension
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    Chapter 15 Hydrogen Sulfide as an O 2 Sensor: A Critical Analysis
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    Chapter 16 Redox Signaling and Persistent Pulmonary Hypertension of the Newborn
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    Chapter 17 Cross Talk Between Mitochondrial Reactive Oxygen Species and Sarcoplasmic Reticulum Calcium in Pulmonary Arterial Smooth Muscle Cells
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    Chapter 18 Endothelial Cell Reactive Oxygen Species and Ca2+ Signaling in Pulmonary Hypertension
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    Chapter 19 Redox Signaling in the Right Ventricle
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    Chapter 20 Hypoxia and Local Inflammation in Pulmonary Artery Structure and Function
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    Chapter 21 From Physiological Redox Signalling to Oxidant Stress
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    Chapter 22 Emerging Role of MicroRNAs and Long Noncoding RNAs in Healthy and Diseased Lung
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    Chapter 23 Techniques for Detecting Reactive Oxygen Species in Pulmonary Vasculature Redox Signaling
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    Chapter 24 Mitochondrial and Metabolic Drivers of Pulmonary Vascular Endothelial Dysfunction in Pulmonary Hypertension
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    Chapter 25 Subcellular Redox Signaling
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    Chapter 26 Reactive Oxygen Species in COPD-Related Vascular Remodeling
Attention for Chapter 4: Pentose Shunt, Glucose-6-Phosphate Dehydrogenase, NADPH Redox, and Stem Cells in Pulmonary Hypertension
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Chapter title
Pentose Shunt, Glucose-6-Phosphate Dehydrogenase, NADPH Redox, and Stem Cells in Pulmonary Hypertension
Chapter number 4
Book title
Pulmonary Vasculature Redox Signaling in Health and Disease
Published in
Advances in experimental medicine and biology, January 2017
DOI 10.1007/978-3-319-63245-2_4
Pubmed ID
29047080
Book ISBNs
978-3-31-963244-5, 978-3-31-963245-2
Authors

Ryota Hashimoto, Sachin Gupte, Hashimoto, Ryota, Gupte, Sachin

Abstract

Redox signaling plays a critical role in the pathophysiology of cardiovascular diseases. The pentose phosphate pathway is a major source of NADPH redox in the cell. The activities of glucose-6-phosphate dehydrogenase (the rate-limiting enzyme in the pentose shunt) and glucose flux through the shunt pathway is increased in various lung cells including, the stem cells, in pulmonary hypertension. This chapter discusses the importance of the shunt pathway and glucose-6-phosphate dehydrogenase in the pathogenesis of pulmonary artery remodeling and occlusive lesion formation within the hypertensive lungs.

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Mendeley readers

The data shown below were compiled from readership statistics for 7 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 7 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 1 14%
Professor 1 14%
Student > Master 1 14%
Researcher 1 14%
Student > Postgraduate 1 14%
Other 0 0%
Unknown 2 29%
Readers by discipline Count As %
Medicine and Dentistry 2 29%
Agricultural and Biological Sciences 1 14%
Biochemistry, Genetics and Molecular Biology 1 14%
Unknown 3 43%

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