Chapter title |
Effects of Hyperoxia on the Developing Airway and Pulmonary Vasculature
|
---|---|
Chapter number | 11 |
Book title |
Pulmonary Vasculature Redox Signaling in Health and Disease
|
Published in |
Advances in experimental medicine and biology, January 2017
|
DOI | 10.1007/978-3-319-63245-2_11 |
Pubmed ID | |
Book ISBNs |
978-3-31-963244-5, 978-3-31-963245-2
|
Authors |
Christina M. Pabelick, Michael A. Thompson, Rodney D. Britt, Pabelick, Christina M., Thompson, Michael A., Britt, Rodney D. |
Abstract |
Although it is necessary and part of standard practice, supplemental oxygen (40-90% O2) or hyperoxia is a significant contributing factor to development of bronchopulmonary dysplasia, persistent pulmonary hypertension, recurrent wheezing, and asthma in preterm infants. This chapter discusses hyperoxia and the role of redox signaling in the context of neonatal lung growth and disease. Here, we discuss how hyperoxia promotes dysfunction in the airway and the known redox-mediated mechanisms that are important for postnatal vascular and alveolar development. Whether in the airway or alveoli, redox pathways are important and greatly influence the neonatal lung. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 11 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 3 | 27% |
Professor > Associate Professor | 1 | 9% |
Student > Bachelor | 1 | 9% |
Researcher | 1 | 9% |
Lecturer | 1 | 9% |
Other | 0 | 0% |
Unknown | 4 | 36% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 3 | 27% |
Biochemistry, Genetics and Molecular Biology | 1 | 9% |
Veterinary Science and Veterinary Medicine | 1 | 9% |
Agricultural and Biological Sciences | 1 | 9% |
Engineering | 1 | 9% |
Other | 0 | 0% |
Unknown | 4 | 36% |