| Chapter title |
ROS Signaling in the Pathogenesis of Acute Lung Injury (ALI) and Acute Respiratory Distress Syndrome (ARDS)
|
|---|---|
| Chapter number | 8 |
| Book title |
Pulmonary Vasculature Redox Signaling in Health and Disease
|
| Published in |
Advances in experimental medicine and biology, January 2017
|
| DOI | 10.1007/978-3-319-63245-2_8 |
| Pubmed ID | |
| Book ISBNs |
978-3-31-963244-5, 978-3-31-963245-2
|
| Authors |
Manuela Kellner, Satish Noonepalle, Qing Lu, Anup Srivastava, Evgeny Zemskov, Stephen M. Black, Kellner, Manuela, Noonepalle, Satish, Lu, Qing, Srivastava, Anup, Zemskov, Evgeny, Black, Stephen M. |
| Abstract |
The generation of reactive oxygen species (ROS) plays an important role for the maintenance of cellular processes and functions in the body. However, the excessive generation of oxygen radicals under pathological conditions such as acute lung injury (ALI) and its most severe form acute respiratory distress syndrome (ARDS) leads to increased endothelial permeability. Within this hallmark of ALI and ARDS, vascular microvessels lose their junctional integrity and show increased myosin contractions that promote the migration of polymorphonuclear leukocytes (PMNs) and the transition of solutes and fluids in the alveolar lumen. These processes all have a redox component, and this chapter focuses on the role played by ROS during the development of ALI/ARDS. We discuss the origins of ROS within the cell, cellular defense mechanisms against oxidative damage, the role of ROS in the development of endothelial permeability, and potential therapies targeted at oxidative stress. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Practitioners (doctors, other healthcare professionals) | 1 | 50% |
| Members of the public | 1 | 50% |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 171 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 20 | 12% |
| Student > Bachelor | 20 | 12% |
| Student > Master | 16 | 9% |
| Student > Ph. D. Student | 15 | 9% |
| Other | 9 | 5% |
| Other | 22 | 13% |
| Unknown | 69 | 40% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 28 | 16% |
| Medicine and Dentistry | 24 | 14% |
| Pharmacology, Toxicology and Pharmaceutical Science | 9 | 5% |
| Agricultural and Biological Sciences | 7 | 4% |
| Immunology and Microbiology | 6 | 4% |
| Other | 20 | 12% |
| Unknown | 77 | 45% |