Chapter title |
A Brief Overview of Nitric Oxide and Reactive Oxygen Species Signaling in Hypoxia-Induced Pulmonary Hypertension
|
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Chapter number | 6 |
Book title |
Pulmonary Vasculature Redox Signaling in Health and Disease
|
Published in |
Advances in experimental medicine and biology, January 2017
|
DOI | 10.1007/978-3-319-63245-2_6 |
Pubmed ID | |
Book ISBNs |
978-3-31-963244-5, 978-3-31-963245-2
|
Authors |
Jaitovich, Ariel, Jourd’heuil, David, Ariel Jaitovich, David Jourd’heuil |
Abstract |
Pulmonary hypertension (PH) is characterized by increased vasoconstriction and smooth muscle cell hyperplasia driving pathological vascular remodeling of arterial vessels. In this short review, we discuss the primary source of reactive oxygen species (ROS) and nitric oxide (NO) relevant to PH and the mechanism by which dysregulation of their production contributes to PH. Specifically, hypoxia-induced PH is associated with diminished endothelial nitric oxide synthase (eNOS)-derived NO production and increased production of superoxide (O2(•-)) through eNOS uncoupling and defective mitochondrial respiration. This drives the inhibition of the NO/soluble guanylate cyclase (sGC) pathway and activation of the transcription factor hypoxia-inducible factor-1α (HIF-1α) with consequential dysregulation of the pulmonary vasculature. Therapeutics aimed at increasing NO or cGMP bioavailabilities are amenable to hypoxia disease-induced PH. Similarly, strategies targeting HIF-1α are now considered. Overall, pulmonary hypertension including hypoxia-induced PH offers unique opportunities for the rational development of therapeutics centered on modulating redox signaling. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 30 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 5 | 17% |
Researcher | 4 | 13% |
Student > Bachelor | 2 | 7% |
Student > Doctoral Student | 2 | 7% |
Professor > Associate Professor | 2 | 7% |
Other | 5 | 17% |
Unknown | 10 | 33% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 8 | 27% |
Biochemistry, Genetics and Molecular Biology | 4 | 13% |
Agricultural and Biological Sciences | 3 | 10% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 7% |
Unspecified | 1 | 3% |
Other | 1 | 3% |
Unknown | 11 | 37% |