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Yeast Membrane Transport

Overview of attention for book
Attention for Chapter 15: Candida Efflux ATPases and Antiporters in Clinical Drug Resistance.
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2 tweeters

Citations

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38 Mendeley
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Chapter title
Candida Efflux ATPases and Antiporters in Clinical Drug Resistance.
Chapter number 15
Book title
Yeast Membrane Transport
Published in
Advances in experimental medicine and biology, January 2016
DOI 10.1007/978-3-319-25304-6_15
Pubmed ID
Book ISBNs
978-3-31-925302-2, 978-3-31-925304-6
Authors

Prasad, Rajendra, Rawal, Manpreet Kaur, Shah, Abdul Haseeb, Rajendra Prasad, Manpreet Kaur Rawal, Abdul Haseeb Shah

Abstract

An enhanced expression of genes encoding ATP binding cassette (ABC) and major facilitator superfamily (MFS) transport proteins are known to contribute to the development of tolerance to antifungals in pathogenic yeasts. For example, the azole resistant (AR) clinical isolates of the opportunistic human fungal pathogen Candida albicans show an overexpression of CDR1 and/or CaMDR1 belonging to ABC and MFS, superfamilies, respectively. The reduced accumulation (due to rapid efflux) of drugs in AR isolates confirms the role of efflux pump proteins in the development of drug tolerance. Considering the importance of major multidrug transporters, the focus of recent research has been to understand the structure and function of these proteins which could help to design inhibitors/modulators of these pump proteins. This chapter focuses on some aspects of the structure and function of yeast transporter proteins particularly in relation to MDR in Candida.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 38 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 38 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 8 21%
Student > Doctoral Student 4 11%
Student > Bachelor 4 11%
Student > Master 4 11%
Professor > Associate Professor 2 5%
Other 4 11%
Unknown 12 32%
Readers by discipline Count As %
Immunology and Microbiology 8 21%
Agricultural and Biological Sciences 4 11%
Biochemistry, Genetics and Molecular Biology 4 11%
Medicine and Dentistry 4 11%
Pharmacology, Toxicology and Pharmaceutical Science 1 3%
Other 4 11%
Unknown 13 34%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 May 2016.
All research outputs
#5,793,728
of 7,659,635 outputs
Outputs from Advances in experimental medicine and biology
#1,339
of 2,205 outputs
Outputs of similar age
#215,335
of 310,798 outputs
Outputs of similar age from Advances in experimental medicine and biology
#355
of 599 outputs
Altmetric has tracked 7,659,635 research outputs across all sources so far. This one is in the 13th percentile – i.e., 13% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,205 research outputs from this source. They receive a mean Attention Score of 3.1. This one is in the 24th percentile – i.e., 24% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 310,798 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 16th percentile – i.e., 16% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 599 others from the same source and published within six weeks on either side of this one. This one is in the 25th percentile – i.e., 25% of its contemporaries scored the same or lower than it.