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Retinal Gene Therapy

Overview of attention for book
Cover of 'Retinal Gene Therapy'

Table of Contents

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    Book Overview
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    Chapter 1 Small Scale Production of Recombinant Adeno-Associated Viral Vectors for Gene Delivery to the Nervous System
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    Chapter 2 Small and Micro-Scale Recombinant Adeno-Associated Virus Production and Purification for Ocular Gene Therapy Applications
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    Chapter 3 Design and Development of AAV-based Gene Supplementation Therapies for Achromatopsia and Retinitis Pigmentosa
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    Chapter 4 Development of Multigenic Lentiviral Vectors for Cell-Specific Expression of Antiangiogenic miRNAs and Protein Factors
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    Chapter 5 Design and In Vitro Use of Antisense Oligonucleotides to Correct Pre-mRNA Splicing Defects in Inherited Retinal Dystrophies
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    Chapter 6 Three-Dimensional Co-Culture Bioassay for Screening of Retinal Gene Delivery Systems
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    Chapter 7 Retinal Gene Therapy for Choroideremia: In Vitro Testing for Gene Augmentation Using an Adeno-Associated Viral (AAV) Vector
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    Chapter 8 In Vivo Electroporation of Developing Mouse Retina
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    Chapter 9 Methods for In Vivo CRISPR/Cas Editing of the Adult Murine Retina
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    Chapter 10 AAV Gene Augmentation Therapy for CRB1-Associated Retinitis Pigmentosa
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    Chapter 11 Dual AAV Vectors for Stargardt Disease
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    Chapter 12 Optogenetic Retinal Gene Therapy with the Light Gated GPCR Vertebrate Rhodopsin
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    Chapter 13 CRISPR Repair Reveals Causative Mutation in a Preclinical Model of Retinitis Pigmentosa: A Brief Methodology
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    Chapter 14 In-Depth Functional Analysis of Rodents by Full-Field Electroretinography
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    Chapter 15 Advanced Ocular Injection Techniques for Therapy Approaches
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    Chapter 16 Neutralizing Antibodies Against Adeno-Associated Virus (AAV): Measurement and Influence on Retinal Gene Delivery
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    Chapter 17 Screening for Neutralizing Antibodies Against Natural and Engineered AAV Capsids in Nonhuman Primate Retinas
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    Chapter 18 Subretinal and Intravitreal Retinal Injections in Monkeys
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    Chapter 19 Production of iPS-Derived Human Retinal Organoids for Use in Transgene Expression Assays
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    Chapter 20 AAV Serotype Testing on Cultured Human Donor Retinal Explants
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    Chapter 21 Human Retinal Explant Culture for Ex Vivo Validation of AAV Gene Therapy
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    Chapter 22 Visual Acuity Testing Before and After Intravitreal Injection of rAAV2-ND4 in Patients
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    Chapter 23 Recording and Analysis of the Human Clinical Electroretinogram
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    Chapter 24 Recording and Analysis of Goldmann Kinetic Visual Fields
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    Chapter 25 Measuring Central Retinal Sensitivity Using Microperimetry
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    Chapter 26 Inspection of the Human Retina by Optical Coherence Tomography
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    Chapter 27 Vector Shedding and Immunogenicity Sampling for Retinal Gene Therapy
Attention for Chapter 17: Screening for Neutralizing Antibodies Against Natural and Engineered AAV Capsids in Nonhuman Primate Retinas
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Chapter title
Screening for Neutralizing Antibodies Against Natural and Engineered AAV Capsids in Nonhuman Primate Retinas
Chapter number 17
Book title
Retinal Gene Therapy
Published in
Methods in molecular biology, January 2018
DOI 10.1007/978-1-4939-7522-8_17
Pubmed ID
29188518
Book ISBNs
978-1-4939-7521-1, 978-1-4939-7522-8
Authors

Timothy P. Day, Leah C. Byrne, John G. Flannery, David V. Schaffer, Day, Timothy P., Byrne, Leah C., Flannery, John G., Schaffer, David V.

Abstract

Adeno-associated virus (AAV) has shown promise as a therapeutic gene delivery vector for inherited retinal degenerations in both preclinical disease models and human clinical trials. The retinas of nonhuman primates (NHPs) share many anatomical similarities to humans and are an important model for evaluating AAV gene delivery. Recent evidence has shown that preexisting immunity in the form of neutralizing antibodies (NABs) in NHPs strongly correlates with weak or lack of AAV transduction in the retina when administered intravitreally, work with translational implications. This necessitates prescreening of NHPs before intravitreal delivery of AAV. In this chapter, we describe a method for screening NHP serum for preexisting NABs.

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X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
 Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 18 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 18 100%

Demographic breakdown

Readers by professional status Count As %
Unspecified 2 11%
Student > Ph. D. Student 2 11%
Student > Postgraduate 2 11%
Professor 2 11%
Student > Doctoral Student 1 6%
Other 2 11%
Unknown 7 39%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 4 22%
Unspecified 2 11%
Medicine and Dentistry 2 11%
Agricultural and Biological Sciences 1 6%
Engineering 1 6%
Other 0 0%
Unknown 8 44%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 July 2018.
All research outputs
#18,577,751
of 23,009,818 outputs
Outputs from Methods in molecular biology
#7,962
of 13,157 outputs
Outputs of similar age
#330,497
of 442,310 outputs
Outputs of similar age from Methods in molecular biology
#950
of 1,498 outputs
Altmetric has tracked 23,009,818 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 13,157 research outputs from this source. They receive a mean Attention Score of 3.4. This one is in the 24th percentile – i.e., 24% of its peers scored the same or lower than it.
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We're also able to compare this research output to 1,498 others from the same source and published within six weeks on either side of this one. This one is in the 20th percentile – i.e., 20% of its contemporaries scored the same or lower than it.

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