Chapter title |
Subretinal and Intravitreal Retinal Injections in Monkeys
|
---|---|
Chapter number | 18 |
Book title |
Retinal Gene Therapy
|
Published in |
Methods in molecular biology, January 2018
|
DOI | 10.1007/978-1-4939-7522-8_18 |
Pubmed ID | |
Book ISBNs |
978-1-4939-7521-1, 978-1-4939-7522-8
|
Authors |
Daniyar Dauletbekov, K. Ulrich Bartz-Schmidt, M. Dominik Fischer |
Abstract |
Ocular anatomy and physiology in cynomolgus monkeys (Macacca fascicularis) are very similar to that found in the human visual system. Therefore and despite significant ethical and economical implications, these animals constitute an excellent model system for toxicology and biodistribution studies in the development of new and meaningful treatment strategies for ocular disorders. The methods for delivery of investigational new drugs (INDs) to the ocular tissue are virtually identical to the methods used in clinical practice. This protocol explains in detail the method of applying INDs to the vitreous cavity or the subretinal space in monkeys. |
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Demographic breakdown
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Researcher | 2 | 40% |
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Unknown | 2 | 40% |
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