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Drug Safety Evaluation

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Cover of 'Drug Safety Evaluation'

Table of Contents

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    Book Overview
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    Chapter 1 Nonclinical Development of Combination Drugs
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    Chapter 2 Juvenile Nonclinical Safety Studies in Support of Pediatric Drug Development
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    Chapter 3 Procedures of Necropsy and Tissue Sampling
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    Chapter 4 Tissue Sampling and Processing for Histopathology Evaluation
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    Chapter 5 Principles and Methods of Immunohistochemistry
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    Chapter 6 Applications of Mass Spectrometry Imaging for Safety Evaluation
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    Chapter 7 In Vivo Rat T-Lymphocyte Pig-a Assay: Detection and Expansion of Cells Deficient in the GPI-Anchored CD48 Surface Marker for Analysis of Mutation in the Endogenous Pig-a Gene
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    Chapter 8 Detection of In Vivo Mutation in the Pig-a Gene of Mouse Bone Marrow Erythroids
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    Chapter 9 The Use of Bacterial Repair Endonucleases in the Comet Assay
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    Chapter 10 Automated Patch-Clamp Methods for the hERG Cardiac Potassium Channel
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    Chapter 11 Impedance Measurement in Induced Pluripotent Stem Cell-Derived Cardiomyocytes
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    Chapter 12 Target Safety Assessment: Strategies and Resources
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    Chapter 13 NMR and MS Methods for Metabolomics
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    Chapter 14 Protocols and Applications of Cellular Metabolomics in Safety Studies Using Precision-Cut Tissue Slices and Carbon 13 NMR
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    Chapter 15 Statistical Analysis of Quantitative RT-PCR Results
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    Chapter 16 Evaluation of Mitochondrial Respiration in Cultured Rat Hepatocytes
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    Chapter 17 FETAX Assay for Evaluation of Developmental Toxicity
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    Chapter 18 Evaluation of Embryotoxicity Using the Zebrafish Model
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    Chapter 19 Absolute Quantification of Toxicological Biomarkers via Mass Spectrometry
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    Chapter 20 Next-Generation Sequencing to Investigate Urinary microRNAs from Macaca fascicularis (Cynomolgus Monkey)
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    Chapter 21 Quantitative RT-PCR for MicroRNAs in Biofluids
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    Chapter 22 Chromogenic In Situ Hybridization Methods for microRNA Biomarker Monitoring of Drug Safety and Efficacy
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    Chapter 23 Urine Exosome Isolation and Characterization
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Title
Drug Safety Evaluation
Published by
Springer New York, January 2017
DOI 10.1007/978-1-4939-7172-5
ISBNs
978-1-4939-7170-1, 978-1-4939-7172-5
Editors

Ph.D. Jean-Charles Gautier

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