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Morpholino Oligomers

Overview of attention for book
Cover of 'Morpholino Oligomers'

Table of Contents

  1. Altmetric Badge
    Book Overview
  2. Altmetric Badge
    Chapter 1 Invention and Early History of Morpholinos: From Pipe Dream to Practical Products
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    Chapter 2 Making a Morpholino Experiment Work: Controls, Favoring Specificity, Improving Efficacy, Storage, and Dose
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    Chapter 3 Aggregation and Disaggregation of Morpholino Oligomers in Solution
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    Chapter 4 End-Modifications on Morpholino Oligos
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    Chapter 5 Inducible Inhibition of Gene Function with Photomorpholinos
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    Chapter 6 Blocking Zebrafish MicroRNAs with Morpholinos
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    Chapter 7 Using Morpholinos to Examine Gene Function During Fin Regeneration
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    Chapter 8 Using Morpholinos to Probe Gene Networks in Sea Urchin
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    Chapter 9 Manipulating Gene Expression in the Chick Embryo
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    Chapter 10 Inhibition of Bacterial Growth by Peptide-Conjugated Morpholino Oligomers
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    Chapter 11 Use of Translation Blocking Morpholinos for Gene Knockdown in Giardia lamblia
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    Chapter 12 Regulation of Isoform Expression by Blocking Polyadenylation Signal Sequences with Morpholinos
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    Chapter 13 Targeting Functional Noncoding RNAs
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    Chapter 14 Use of Morpholino Oligomers for Pretargeting
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    Chapter 15 Diagnostic Applications of Morpholinos and Label-Free Electrochemical Detection of Nucleic Acids
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    Chapter 16 Intranasal Delivery of Peptide-Morpholinos to Knockdown Influenza Host Factors in Mice
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    Chapter 17 Systemic Delivery of Morpholinos to Skip Multiple Exons in a Dog Model of Duchenne Muscular Dystrophy
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    Chapter 18 In Vivo and Explant Electroporation of Morpholinos in the Developing Mouse Retina
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    Chapter 19 Intracerebroventricular Delivery in Mice for Motor Neuron Diseases
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    Chapter 20 Delivery of Morpholino Antisense Oligonucleotides to a Developing Ovine Conceptus via Luminal Injection into a Ligated Uterine Horn
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    Chapter 21 Surface Plasmon Resonance-Based Concentration Determination Assay: Label-Free and Antibody-Free Quantification of Morpholinos
  23. Altmetric Badge
    Chapter 22 Ultrasensitive Hybridization-Based ELISA Method for the Determination of Phosphorodiamidate Morpholino Oligonucleotides in Biological samples
Attention for Chapter 1: Invention and Early History of Morpholinos: From Pipe Dream to Practical Products
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (62nd percentile)
  • High Attention Score compared to outputs of the same age and source (88th percentile)

Mentioned by

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1 X user
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4 Wikipedia pages

Citations

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16 Dimensions

Readers on

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31 Mendeley
Summary X Wikipedia Dimensions citations
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Chapter title
Invention and Early History of Morpholinos: From Pipe Dream to Practical Products
Chapter number 1
Book title
Morpholino Oligomers
Published in
Methods in molecular biology, April 2017
DOI 10.1007/978-1-4939-6817-6_1
Pubmed ID
28364229
Book ISBNs
978-1-4939-6815-2, 978-1-4939-6817-6
Authors

James E. Summerton, Summerton, James E.

Editors

Hong M. Moulton, Jon D. Moulton

Abstract

Beginning with my concept in 1969 to treat disease at the nucleic acid level using antisense nucleic acids, antisense has evolved to the current Morpholino oligos. Morpholinos have been the dominant gene knockdown system in developmental biology. Lack of delivery technologies has limited their use in adult animals (including humans), though alteration in muscles in Duchenne muscular dystrophy (DMD) allows delivery into adult muscle. Morpholinos are currently in Phase 3 clinical trials for DMD and a Morpholino oligo for skipping dystrophin exon 51 has been approved by the US FDA. With improved delivery techniques, such as those in development at Gene Tools, therapeutic Morpholinos for many difficult-to-treat diseases will be possible. Initial applications are expected to be custom cocktails of delivery-enabled Morpholinos for treating cancers.

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X Demographics

X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
 Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 31 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 31 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 6 19%
Researcher 4 13%
Student > Master 4 13%
Student > Bachelor 3 10%
Professor 2 6%
Other 2 6%
Unknown 10 32%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 9 29%
Chemistry 6 19%
Pharmacology, Toxicology and Pharmaceutical Science 2 6%
Medicine and Dentistry 1 3%
Agricultural and Biological Sciences 1 3%
Other 0 0%
Unknown 12 39%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 October 2023.
All research outputs
#7,749,485
of 24,857,051 outputs
Outputs from Methods in molecular biology
#2,324
of 13,965 outputs
Outputs of similar age
#114,979
of 314,912 outputs
Outputs of similar age from Methods in molecular biology
#35
of 285 outputs
Altmetric has tracked 24,857,051 research outputs across all sources so far. This one has received more attention than most of these and is in the 68th percentile.
So far Altmetric has tracked 13,965 research outputs from this source. They receive a mean Attention Score of 3.5. This one has done well, scoring higher than 82% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 314,912 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 62% of its contemporaries.
We're also able to compare this research output to 285 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 88% of its contemporaries.

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