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Morpholino Oligomers

Overview of attention for book
Cover of 'Morpholino Oligomers'

Table of Contents

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    Book Overview
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    Chapter 1 Invention and Early History of Morpholinos: From Pipe Dream to Practical Products
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    Chapter 2 Making a Morpholino Experiment Work: Controls, Favoring Specificity, Improving Efficacy, Storage, and Dose
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    Chapter 3 Aggregation and Disaggregation of Morpholino Oligomers in Solution
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    Chapter 4 End-Modifications on Morpholino Oligos
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    Chapter 5 Inducible Inhibition of Gene Function with Photomorpholinos
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    Chapter 6 Blocking Zebrafish MicroRNAs with Morpholinos
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    Chapter 7 Using Morpholinos to Examine Gene Function During Fin Regeneration
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    Chapter 8 Using Morpholinos to Probe Gene Networks in Sea Urchin
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    Chapter 9 Manipulating Gene Expression in the Chick Embryo
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    Chapter 10 Inhibition of Bacterial Growth by Peptide-Conjugated Morpholino Oligomers
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    Chapter 11 Use of Translation Blocking Morpholinos for Gene Knockdown in Giardia lamblia
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    Chapter 12 Regulation of Isoform Expression by Blocking Polyadenylation Signal Sequences with Morpholinos
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    Chapter 13 Targeting Functional Noncoding RNAs
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    Chapter 14 Use of Morpholino Oligomers for Pretargeting
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    Chapter 15 Diagnostic Applications of Morpholinos and Label-Free Electrochemical Detection of Nucleic Acids
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    Chapter 16 Intranasal Delivery of Peptide-Morpholinos to Knockdown Influenza Host Factors in Mice
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    Chapter 17 Systemic Delivery of Morpholinos to Skip Multiple Exons in a Dog Model of Duchenne Muscular Dystrophy
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    Chapter 18 In Vivo and Explant Electroporation of Morpholinos in the Developing Mouse Retina
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    Chapter 19 Intracerebroventricular Delivery in Mice for Motor Neuron Diseases
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    Chapter 20 Delivery of Morpholino Antisense Oligonucleotides to a Developing Ovine Conceptus via Luminal Injection into a Ligated Uterine Horn
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    Chapter 21 Surface Plasmon Resonance-Based Concentration Determination Assay: Label-Free and Antibody-Free Quantification of Morpholinos
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    Chapter 22 Ultrasensitive Hybridization-Based ELISA Method for the Determination of Phosphorodiamidate Morpholino Oligonucleotides in Biological samples
Attention for Chapter 15: Diagnostic Applications of Morpholinos and Label-Free Electrochemical Detection of Nucleic Acids
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Chapter title
Diagnostic Applications of Morpholinos and Label-Free Electrochemical Detection of Nucleic Acids
Chapter number 15
Book title
Morpholino Oligomers
Published in
Methods in molecular biology, April 2017
DOI 10.1007/978-1-4939-6817-6_15
Pubmed ID
28364243
Book ISBNs
978-1-4939-6815-2, 978-1-4939-6817-6
Authors

Levicky, Rastislav, Koniges, Ursula, Tercero, Napoleon, Rastislav Levicky, Ursula Koniges, Napoleon Tercero

Editors

Hong M. Moulton, Jon D. Moulton

Abstract

Diagnostic applications of morpholinos take advantage of their unique properties including backbone charge neutrality, a weak impact of ionic strength on their hybridization behavior, and their resistance to enzymatic degradation. This chapter overviews how these properties have advanced transduction and other capabilities useful for the analysis of nucleic acids. In many cases, the benefits stem from electrostatic mechanisms; for example, use of low ionic strengths improves sensitivity of detection while decreasing background signals because only the nucleic acid analyte is charged. While most literature reports focus on in vitro assays in buffer, morpholinos have been also used for biodistribution measurements of species such as fungal rRNA and miRNA. After reviewing the diagnostic applications of morpholinos, the chapter describes preparation of morpholino monolayers on metal supports for electrochemical diagnostics and the procedure for performing label-free detection of DNA from changes in surface capacitance.

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X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
 Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 9 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 9 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 2 22%
Student > Postgraduate 2 22%
Student > Ph. D. Student 1 11%
Professor > Associate Professor 1 11%
Student > Bachelor 1 11%
Other 0 0%
Unknown 2 22%
Readers by discipline Count As %
Engineering 3 33%
Biochemistry, Genetics and Molecular Biology 2 22%
Medicine and Dentistry 1 11%
Chemistry 1 11%
Unknown 2 22%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 April 2017.
All research outputs
#20,967,244
of 23,599,923 outputs
Outputs from Methods in molecular biology
#10,166
of 13,346 outputs
Outputs of similar age
#271,353
of 310,538 outputs
Outputs of similar age from Methods in molecular biology
#227
of 289 outputs
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So far Altmetric has tracked 13,346 research outputs from this source. They receive a mean Attention Score of 3.4. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 310,538 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 289 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.

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