Chapter title |
Predictive Factors for Outcome and Quality of Life in HPV-Positive and HPV-Negative HNSCC
|
---|---|
Chapter number | 18 |
Book title |
HPV Infection in Head and Neck Cancer
|
Published in |
Recent results in cancer research Fortschritte der Krebsforschung Progrès dans les recherches sur le cancer, October 2016
|
DOI | 10.1007/978-3-319-43580-0_18 |
Pubmed ID | |
Book ISBNs |
978-3-31-943578-7, 978-3-31-943580-0
|
Authors |
Jochen Hess |
Editors |
Wojciech Golusiński, C. René Leemans, Andreas Dietz |
Abstract |
Infection with high-risk types of the human papilloma virus (HPV) is an etiological risk factor for oropharyngeal squamous cell carcinoma (OPSCC) and associated with a better response to therapy and improved survival. A better understanding of the molecular principles underlying the differences in clinical behavior could pave the way to establish more effective and less toxic therapy for HPV-positive OPSCC and their HPV-negative counterparts. Compelling experimental evidence demonstrates that extensive global reprogramming of epigenetic profiles is as important as genetic mutations during neoplastic transformation and malignant progression, including HPV-positive OPSCC. In this chapter, the current knowledge on HPV-related alterations in DNA methylation, histone modification, and chromosome remodeling will be summarized and assessment of cancer-related profiles will be discussed as a valuable tool to gain important diagnostic or prognostic information for therapeutic decision-making and clinical management of HNSCC patients. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Netherlands | 1 | 3% |
Unknown | 29 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 7 | 23% |
Student > Bachelor | 5 | 17% |
Student > Doctoral Student | 3 | 10% |
Researcher | 3 | 10% |
Student > Ph. D. Student | 2 | 7% |
Other | 5 | 17% |
Unknown | 5 | 17% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 8 | 27% |
Biochemistry, Genetics and Molecular Biology | 7 | 23% |
Nursing and Health Professions | 2 | 7% |
Agricultural and Biological Sciences | 2 | 7% |
Immunology and Microbiology | 1 | 3% |
Other | 1 | 3% |
Unknown | 9 | 30% |