| Chapter title |
HPV Infection in Head and Neck Cancer
|
|---|---|
| Chapter number | 12 |
| Book title |
HPV Infection in Head and Neck Cancer
|
| Published in |
Recent results in cancer research Fortschritte der Krebsforschung Progrès dans les recherches sur le cancer, October 2016
|
| DOI | 10.1007/978-3-319-43580-0_12 |
| Pubmed ID | |
| Book ISBNs |
978-3-31-943578-7, 978-3-31-943580-0
|
| Authors |
Langendijk, Johannes A, Steenbakkers, Roel J H M, Langendijk, Johannes A., Steenbakkers, Roel J.H.M., Johannes A. Langendijk, Roel J.H.M. Steenbakkers |
| Editors |
Wojciech Golusiński, C. René Leemans, Andreas Dietz |
| Abstract |
Concurrent chemoradiation is considered the golden standard in the treatment of locally advanced OPC. However, given the very high survival rates in favorable HPV-positive OPC and the high rates of acute and late treatment-related side effects, de-escalation strategies have to be considered. In this chapter, the potential benefit of a number of de-escalation strategies is described, including of replacement of concurrent chemotherapy by cetuximab, radiation dose de-escalation based on response to induction chemotherapy, radiotherapy alone without systemic treatment, and limiting elective nodal target volumes for radiation. In addition to de-escalation, modern radiation technologies like protons will offer increasing opportunities to decrease the dose to normal tissues in order to prevent radiation-induced toxicities. Initial analysis showed that radiation dose de-escalation based on response to induction chemotherapy in combination with intensity-modulated proton therapy (IMPT) has the highest potential to decrease acute and late toxicities. |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 42 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 4 | 10% |
| Student > Postgraduate | 4 | 10% |
| Student > Bachelor | 2 | 5% |
| Professor | 2 | 5% |
| Student > Doctoral Student | 1 | 2% |
| Other | 4 | 10% |
| Unknown | 25 | 60% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 8 | 19% |
| Biochemistry, Genetics and Molecular Biology | 1 | 2% |
| Business, Management and Accounting | 1 | 2% |
| Nursing and Health Professions | 1 | 2% |
| Arts and Humanities | 1 | 2% |
| Other | 4 | 10% |
| Unknown | 26 | 62% |