Chapter title |
Tumor Staging and HPV-Related Oropharyngeal Cancer
|
---|---|
Chapter number | 9 |
Book title |
HPV Infection in Head and Neck Cancer
|
Published in |
Recent results in cancer research Fortschritte der Krebsforschung Progrès dans les recherches sur le cancer, October 2016
|
DOI | 10.1007/978-3-319-43580-0_9 |
Pubmed ID | |
Book ISBNs |
978-3-31-943578-7, 978-3-31-943580-0
|
Authors |
Claus Wittekindt, Jens Peter Klussmann |
Editors |
Wojciech Golusiński, C. René Leemans, Andreas Dietz |
Abstract |
The current TNM staging for oropharyngeal cancer (OSCC) was designed empirically for non-HPV-related disease. Emerging evidence suggests it is unsuited for Human papillomavirus (HPV)-related OSCC. Patients with HPV-positive tumors have improved prognosis, despite presenting at advanced stages. These shortcomings of the current staging system have been identified in single- and multi-institutional trials. Patients with HPV related OSCC typically present with advanced N-stages leading to higher stage groupings. A rarity of stages I and II therefore represents the nature of HPV-related OSCC. Concerning prognosis of the patients, N-category and extracapsular spread seem to be of minor importance, whereas advanced T-stages result in unfavourable outcome. Anatomical staging therefore has been implied into different proposals to prognostic risk classifications in HPV-related disease as an additive compound. Prognostic risk groupings are further enhanced by incorporating non-anatomical factors. To summarize, it can be suggested that the current TNM system alone has little prognostic value in HPV-related OSCC. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 28 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 8 | 29% |
Student > Doctoral Student | 4 | 14% |
Student > Postgraduate | 3 | 11% |
Researcher | 3 | 11% |
Other | 2 | 7% |
Other | 4 | 14% |
Unknown | 4 | 14% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 12 | 43% |
Agricultural and Biological Sciences | 2 | 7% |
Biochemistry, Genetics and Molecular Biology | 2 | 7% |
Linguistics | 1 | 4% |
Nursing and Health Professions | 1 | 4% |
Other | 5 | 18% |
Unknown | 5 | 18% |