Chapter title |
Systemic Treatment in HPV-Induced Recurrent or Metastatic HNSCC
|
---|---|
Chapter number | 11 |
Book title |
HPV Infection in Head and Neck Cancer
|
Published in |
Recent results in cancer research Fortschritte der Krebsforschung Progrès dans les recherches sur le cancer, October 2016
|
DOI | 10.1007/978-3-319-43580-0_11 |
Pubmed ID | |
Book ISBNs |
978-3-31-943578-7, 978-3-31-943580-0
|
Authors |
Damian T. Rieke, Ulrich Keilholz |
Editors |
Wojciech Golusiński, C. René Leemans, Andreas Dietz |
Abstract |
Recurrent or metastatic head and neck cancer describes tumor deposits that arise locally, regionally, or at distant sites after treatment or distant metastases at the time of primary diagnosis. Prognosis for R/M squamous cell carcinomas of the head and neck (HNSCC) is poor and treatment options are limited in this situation. Human papillomavirus (HPV) is an important risk factor for HNSCC. About 40 % of all HNSCC have been attributed to HPV in Europe. HPV positivity at initial diagnosis is the single best prognostic factor for survival. However, data for the prognostic and predictive value of HPV in the R/M situation are still scarce. Due to the rising incidence of HPV-associated cancers, the number of R/M HPV+ carcinomas is also expected to rise. This chapter therefore aims to give an overview of the current knowledge concerning the role of HPV as a prognostic and predictive marker in recurrent or metastatic HNSCC. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Netherlands | 1 | 4% |
Unknown | 22 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 3 | 13% |
Student > Postgraduate | 3 | 13% |
Student > Ph. D. Student | 3 | 13% |
Other | 2 | 9% |
Student > Bachelor | 2 | 9% |
Other | 3 | 13% |
Unknown | 7 | 30% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 9 | 39% |
Biochemistry, Genetics and Molecular Biology | 2 | 9% |
Arts and Humanities | 1 | 4% |
Immunology and Microbiology | 1 | 4% |
Nursing and Health Professions | 1 | 4% |
Other | 0 | 0% |
Unknown | 9 | 39% |