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Chapter title |
Generation of Tissue-Specific Mouse Models to Analyze HDAC Functions
|
---|---|
Chapter number | 13 |
Book title |
HDAC/HAT Function Assessment and Inhibitor Development
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Published in |
Methods in molecular biology, January 2017
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DOI | 10.1007/978-1-4939-6527-4_13 |
Pubmed ID | |
Book ISBNs |
978-1-4939-6525-0, 978-1-4939-6527-4
|
Authors |
Astrid Hagelkruys, Mirjam A. Moser, Christian Seiser |
Editors |
Oliver H. Krämer |
Abstract |
Histone deacetylases (HDACs) play crucial roles during mammalian development and for cellular homeostasis. In addition, these enzymes are promising targets for small molecule inhibitors in the treatment of cancer and neurological diseases. Conditional HDAC knock-out mice are excellent tools for defining the functions of individual HDACs in vivo and for identifying the molecular targets of HDAC inhibitors in disease. Here, we describe the generation of tissue-specific HDAC knock-out mice and delineate a strategy for the generation of conditional HDAC knock-in mice. |
Mendeley readers
The data shown below were compiled from readership statistics for 5 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 5 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 2 | 40% |
Librarian | 1 | 20% |
Researcher | 1 | 20% |
Student > Master | 1 | 20% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 3 | 60% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 20% |
Agricultural and Biological Sciences | 1 | 20% |