Chapter title |
Molecular Detection of Resistance to Echinocandins.
|
---|---|
Chapter number | 23 |
Book title |
Human Fungal Pathogen Identification
|
Published in |
Methods in molecular biology, January 2017
|
DOI | 10.1007/978-1-4939-6515-1_23 |
Pubmed ID | |
Book ISBNs |
978-1-4939-6513-7, 978-1-4939-6515-1
|
Authors |
Brunella Posteraro, Antonietta Vella, Elena De Carolis, Maurizio Sanguinetti |
Editors |
Thomas Lion |
Abstract |
In the last years, life-threatening fungal diseases have increased significantly, due to the rising number of human individuals susceptible to fungal infections, which are in part complicated by the emergence of antifungal drug-resistant pathogens. Among yeasts, Candida albicans and Candida glabrata are the most common organisms responsible for invasive fungal diseases. The molecular detection of echinocandin resistance in Candida species may represent a useful means of monitoring the incidence of clinical isolates with antifungal resistance-associated gene alterations. Here, we describe the current methods that enable researchers and/or clinical microbiologists to accurately detect echinocandin-resistant isolates of C. albicans and C. glabrata. |
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