Chapter title |
The Benefits of Natural Products for Neurodegenerative Diseases
|
---|---|
Chapter number | 14 |
Book title |
The Benefits of Natural Products for Neurodegenerative Diseases
|
Published in |
Advances in neurobiology, September 2016
|
DOI | 10.1007/978-3-319-28383-8_14 |
Pubmed ID | |
Book ISBNs |
978-3-31-928381-4, 978-3-31-928383-8
|
Authors |
Soeda, Shinji, Aritake, Kosuke, Urade, Yoshihiro, Sato, Hiroshi, Shoyama, Yukihiro, Shinji Soeda, Kosuke Aritake, Yoshihiro Urade, Hiroshi Sato, Yukihiro Shoyama |
Editors |
M. Mohamed Essa, Mohammed Akbar, Gilles Guillemin |
Abstract |
We first considered that saffron is really safety food because it has a long-use history. The neuroprotective activities of saffron and its major constituent, crocin, are separately discussed in vitro and in vivo. We reviewed the inhibitory activities of crocin against PC-12 cell apoptosis. The oxidative stress decreased the cellular levels of glutathione (GSH) which is an inhibitor of neutral sphingomyelinase (N-SMase). Therefore, the level of GSH was assayed by the addition of crocin resulted in the activation of glutathione reductase (GR). It became evident that crocin treatment prevents the N-SMase activation resulting in the decrease of ceramide release. From these evidences we summarized the role of crocin for neuronal cell death. We used the ethanol-blocking assay system for learning and memory activities. The effect of saffron and crocin on improving ethanol-induced impairment of learning behaviors of mice in passive avoidance tasks has been clear. Further, we did make clear that saffron and crocin prevent the inhibitory effect of ethanol on long-term potentiation (LTP) in the dentate gyrus. Finally we found that 100 mg/kg of crocin gave non-rapid eye movement sleep (non-REM sleep) although mice were started to be active during night time. |
X Demographics
As of 1 July 2024, you may notice a temporary increase in the numbers of X profiles with Unknown location. Click here to learn more.
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 24 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 4 | 17% |
Student > Bachelor | 4 | 17% |
Student > Ph. D. Student | 3 | 13% |
Professor > Associate Professor | 2 | 8% |
Student > Doctoral Student | 1 | 4% |
Other | 4 | 17% |
Unknown | 6 | 25% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 6 | 25% |
Pharmacology, Toxicology and Pharmaceutical Science | 3 | 13% |
Biochemistry, Genetics and Molecular Biology | 2 | 8% |
Agricultural and Biological Sciences | 2 | 8% |
Unspecified | 1 | 4% |
Other | 3 | 13% |
Unknown | 7 | 29% |