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The Benefits of Natural Products for Neurodegenerative Diseases

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Cover of 'The Benefits of Natural Products for Neurodegenerative Diseases'

Table of Contents

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    Book Overview
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    Chapter 1 The Benefits of Natural Products for Neurodegenerative Diseases
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    Chapter 2 The Benefits of Natural Products for Neurodegenerative Diseases
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    Chapter 3 The Benefits of Natural Products for Neurodegenerative Diseases
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    Chapter 4 The Benefits of Natural Products for Neurodegenerative Diseases
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    Chapter 5 The Benefits of Natural Products for Neurodegenerative Diseases
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    Chapter 6 The Benefits of Natural Products for Neurodegenerative Diseases
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    Chapter 7 The Benefits of Natural Products for Neurodegenerative Diseases
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    Chapter 8 Impact of Non-Enzymatic Glycation in Neurodegenerative Diseases: Role of Natural Products in Prevention.
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    Chapter 9 The Benefits of Natural Products for Neurodegenerative Diseases
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    Chapter 10 The Benefits of Natural Products for Neurodegenerative Diseases
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    Chapter 11 The Benefits of Natural Products for Neurodegenerative Diseases
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    Chapter 12 The Benefits of Natural Products for Neurodegenerative Diseases
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    Chapter 13 The Benefits of Natural Products for Neurodegenerative Diseases
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    Chapter 14 The Benefits of Natural Products for Neurodegenerative Diseases
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    Chapter 15 The Benefits of Natural Products for Neurodegenerative Diseases
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    Chapter 16 The Benefits of Natural Products for Neurodegenerative Diseases
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    Chapter 17 Indian Herbs for the Treatment of Neurodegenerative Disease.
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    Chapter 18 Avocado as a Major Dietary Source of Antioxidants and Its Preventive Role in Neurodegenerative Diseases.
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    Chapter 19 The Benefits of Natural Products for Neurodegenerative Diseases
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    Chapter 20 Role of Polyunsaturated Fatty Acids and Their Metabolites on Stem Cell Proliferation and Differentiation.
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    Chapter 21 The Benefits of Natural Products for Neurodegenerative Diseases
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    Chapter 22 Modulatory Effects of Dietary Amino Acids on Neurodegenerative Diseases.
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    Chapter 23 Plant-Derived Natural Products for Parkinson's Disease Therapy.
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    Chapter 24 Erratum
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Chapter title
The Benefits of Natural Products for Neurodegenerative Diseases
Chapter number 7
Book title
The Benefits of Natural Products for Neurodegenerative Diseases
Published in
Advances in neurobiology, September 2016
DOI 10.1007/978-3-319-28383-8_7
Pubmed ID
Book ISBNs
978-3-31-928381-4, 978-3-31-928383-8
Authors

Srivastava, Pranay, Yadav, Rajesh Singh, Pranay Srivastava, Rajesh Singh Yadav

Editors

M. Mohamed Essa, Mohammed Akbar, Gilles Guillemin

Abstract

Neurodegenerative disorders represent clusters of serious diseases that results in progressive deterioration of normal structure and physiology of central nervous system. Pathophysiology of Alzheimer's, Parkinson's or other neurodegenerative disorders involves multifaceted permutation of genetic and environmental factors. Combinations of lifestyle modification linked with environmental factor jointly or alone represent the largest share of cases of these disorders. Etiology of such neuronal degeneration involves manifestation of toxic reaction in the form of functional anomalies leading to dysfunction of the ubiquitin-proteasome system, activated inflammatory cascade, compromised neuronal survival pathway, mitochondrial dysfunction and finally neuronal apoptosis/necrosis and cell death. Furthermore, evidences from various studies exhibited role of oxidative stress and compromised anti-oxidant defense system as one of the prime factors associated with activation of various signal transduction pathways that would ultimately lead to the formation of amyloid beta or alpha synuclein in the brain. Keeping in view of complex etiology and pathophysiology along with a miniscule of available treatment options associated with these neurodegenerative disorders, the role of natural agents and herbal extracts as therapeutic alternatives alone or in combination with synthetic drugs could not be ruled out. In the same context the present chapter has been aimed to investigate the role of selected natural plants like Withania somnifera, Bacopa monnieri, Curcuma longa, Centella asiatica, Ocimum sanctum, Nardostachys jatamansi and Emblica officinalis in various neurodegenerative disorders and explore their targets to ameliorate neurotoxicity in various experimental models. The rationale for selection of these plants was based on their strong anti-inflammatory and anti-oxidant potential and large body of evidence that suggest their efficacy in preclinical as well as in clinical studies. Active constituents if these herbals might play an important role in preserving the integrity of various neurotransmitters and their receptor in the brain influencing its functions at the molecular level.

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The data shown below were compiled from readership statistics for 80 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 80 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 13 16%
Student > Ph. D. Student 11 14%
Student > Bachelor 9 11%
Researcher 7 9%
Lecturer 4 5%
Other 11 14%
Unknown 25 31%
Readers by discipline Count As %
Medicine and Dentistry 13 16%
Pharmacology, Toxicology and Pharmaceutical Science 10 13%
Neuroscience 7 9%
Agricultural and Biological Sciences 6 8%
Biochemistry, Genetics and Molecular Biology 6 8%
Other 7 9%
Unknown 31 39%