Chapter title |
Natural Killer Cells
|
---|---|
Chapter number | 27 |
Book title |
Natural Killer Cells
|
Published in |
Methods in molecular biology, January 2016
|
DOI | 10.1007/978-1-4939-3684-7_27 |
Pubmed ID | |
Book ISBNs |
978-1-4939-3682-3, 978-1-4939-3684-7
|
Authors |
Somanchi, Srinivas S, Kennis, Bridget A, Gopalakrishnan, Vidya, Lee, Dean A, Bankson, James A, Srinivas S. Somanchi, Bridget A. Kennis, Vidya Gopalakrishnan, Dean A. Lee, James A. Bankson Ph.D., Somanchi, Srinivas S., Kennis, Bridget A., Lee, Dean A., Bankson, James A., James A. Bankson |
Editors |
Srinivas S. Somanchi |
Abstract |
In order to assess the biodistribution, homing, and persistence of adoptively transferred natural killer (NK) cell immunotherapies, there is a need for imaging methodology suitable for use in preclinical studies with relevance to clinical translation. Amongst the available approaches, (19)F-MRI is very appealing for in vivo imaging due to the absence of background signal, enabling clear detection of (19)F labeled cells in vivo. Here we describe a methodology for in vivo imaging of adoptively transferred NK cells labeled with (19)F nano-emulsion, using clinically translatable technology of (19)F/(1)H magnetic resonance imaging. |
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