Chapter title |
Natural Killer Cells
|
---|---|
Chapter number | 1 |
Book title |
Natural Killer Cells
|
Published in |
Methods in molecular biology, January 2016
|
DOI | 10.1007/978-1-4939-3684-7_1 |
Pubmed ID | |
Book ISBNs |
978-1-4939-3682-3, 978-1-4939-3684-7
|
Authors |
Beaulieu, Aimee M, Sun, Joseph C, Aimee M. Beaulieu, Joseph C. Sun Ph.D., Joseph C. Sun |
Editors |
Srinivas S. Somanchi |
Abstract |
In C57BL/6 mice, NK cells expressing the activating receptor Ly49H proliferate robustly in response to mouse cytomegalovirus (MCMV) infection. The expansion of Ly49H(+) NK cells peaks at approximately 1 week post-infection, and is then followed by a distinct contraction phase that ultimately leaves a small but long-lived pool of MCMV-experienced Ly49H(+) NK cells that are capable of mediating enhanced memory-like responses during subsequent encounters with MCMV. Here we describe an adoptive transfer model in which the expansion, contraction, and memory cell persistence of transferred Ly49H(+) NK cells are tracked in congenic C57BL/6 hosts following MCMV infection. |
X Demographics
Geographical breakdown
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Unknown | 2 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 14 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 3 | 21% |
Student > Bachelor | 2 | 14% |
Researcher | 2 | 14% |
Student > Master | 1 | 7% |
Student > Doctoral Student | 1 | 7% |
Other | 0 | 0% |
Unknown | 5 | 36% |
Readers by discipline | Count | As % |
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Immunology and Microbiology | 4 | 29% |
Biochemistry, Genetics and Molecular Biology | 1 | 7% |
Agricultural and Biological Sciences | 1 | 7% |
Medicine and Dentistry | 1 | 7% |
Chemistry | 1 | 7% |
Other | 1 | 7% |
Unknown | 5 | 36% |