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DNA Nanotechnology

Overview of attention for book
Cover of 'DNA Nanotechnology'

Table of Contents

  1. Altmetric Badge
    Book Overview
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    Chapter 1 DNA Nanotechnology: From the Pub to Information-Based Chemistry
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    Chapter 2 The Synthesis of Designer DNA
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    Chapter 3 Synthesis of DNA-Based Nanowires
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    Chapter 4 Preparation of Anti-miR PNAs for Drug Development and Nanomedicine
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    Chapter 5 Loading of PNA and Other Molecular Payloads on Inorganic Nanostructures for Theranostics
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    Chapter 6 Design and Characterization of pH-Triggered DNA Nanoswitches and Nanodevices Based on DNA Triplex Structures
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    Chapter 7 Characterizing Surface-Immobilized DNA Structures and Devices Using a Quartz Crystal Microbalance with Dissipation Monitoring (QCM-D)
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    Chapter 8 Hybridization Chain Reaction Design and Biosensor Implementation
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    Chapter 9 Ultrasensitive Detection of Metal Ions with DNA Nanostructure
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    Chapter 10 Spatially Resolved Peptide-DNA Nanoassemblages for Biomarker Detection: A Synergy of DNA-Directed Immobilization and Nanografting
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    Chapter 11 LSPR Detection of Nucleic Acids on Nanoparticle Monolayers
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    Chapter 12 DNA-Templated Silver Nanoclusters for DNA Methylation Detection
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    Chapter 13 Selection of Structure-Switching DNA Aptamers Binding Soluble Small Molecules and SPR Validation of Enrichment
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    Chapter 14 Dielectrophoretic Stretching of DNA
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    Chapter 15 A Practical Guide to Molecular Dynamics Simulations of DNA Origami Systems
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    Chapter 16 Single-Molecule Patterning via DNA Nanostructure Assembly: A Reusable Platform
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    Chapter 17 Directed Protein Adsorption Through DNA Origami Masks
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    Chapter 18 DNA Origami Structures Interfaced to Inorganic Nanodevices
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    Chapter 19 Tuning Gold Nanoparticles Plasmonic Properties by DNA Nanotechnology
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    Chapter 20 DNA-Assisted Molecular Lithography
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    Chapter 21 Constructing Free Energy Landscapes of Nucleic Acid Hairpin Unfolding
Attention for Chapter 21: Constructing Free Energy Landscapes of Nucleic Acid Hairpin Unfolding
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Chapter title
Constructing Free Energy Landscapes of Nucleic Acid Hairpin Unfolding
Chapter number 21
Book title
DNA Nanotechnology
Published in
Methods in molecular biology, January 2018
DOI 10.1007/978-1-4939-8582-1_21
Pubmed ID
29926462
Book ISBNs
978-1-4939-8581-4, 978-1-4939-8582-1
Authors

Micah J. McCauley, Ioulia Rouzina, Mark C. Williams, McCauley, Micah J., Rouzina, Ioulia, Williams, Mark C.

Abstract

Single nucleic acid molecules form hairpins that may stabilize secondary and tertiary structures as well as perform enzymatic and other chemical functions. Considerable progress has been made in the effort to understand the contributions of various factors to the stability of a given hairpin sequence. For a given sequence, it is possible to compute both the most likely structural arrangements and their associated free energies over a range of experimental conditions. However, there are many observed hairpin irregularities for which the energies and function are not well understood. Here we examine the irregular RNA Transactivation Response (TAR) hairpin from the HIV-1 genome. Using single molecule optical tweezers, the hairpin is force unfolded, revealing the overall unfolding free energy and the character of the transition state. These measurements allow the construction of a simple energy landscape from unfolding measurements, which can be directly compared to a theoretical landscape. This method is easily adapted to other structures, including the effects of noncanonical bases and even ligand binding.

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X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
 Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 2 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 2 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 1 50%
Student > Doctoral Student 1 50%
Readers by discipline Count As %
Agricultural and Biological Sciences 1 50%
Physics and Astronomy 1 50%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 March 2019.
All research outputs
#15,538,060
of 23,092,602 outputs
Outputs from Methods in molecular biology
#5,410
of 13,207 outputs
Outputs of similar age
#270,127
of 442,634 outputs
Outputs of similar age from Methods in molecular biology
#596
of 1,499 outputs
Altmetric has tracked 23,092,602 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 13,207 research outputs from this source. They receive a mean Attention Score of 3.4. This one is in the 44th percentile – i.e., 44% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 442,634 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 29th percentile – i.e., 29% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 1,499 others from the same source and published within six weeks on either side of this one. This one is in the 42nd percentile – i.e., 42% of its contemporaries scored the same or lower than it.

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