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Mendeley readers
| Chapter title |
Preparation of Anti-miR PNAs for Drug Development and Nanomedicine
|
|---|---|
| Chapter number | 4 |
| Book title |
DNA Nanotechnology
|
| Published in |
Methods in molecular biology, January 2018
|
| DOI | 10.1007/978-1-4939-8582-1_4 |
| Pubmed ID | |
| Book ISBNs |
978-1-4939-8581-4, 978-1-4939-8582-1
|
| Authors |
Alex Manicardi, Roberto Gambari, Luisa de Cola, Roberto Corradini, Manicardi, Alex, Gambari, Roberto, Cola, Luisa de, Corradini, Roberto |
| Abstract |
Peptide Nucleic Acids (PNAs) are oligonucleotide mimics that can be used to block the biological action of microRNA, thus affecting gene expression post-transcriptionally. PNAs are obtained with solid-phase peptide synthesis, and can be easily conjugated to other peptides. Conjugation with R8-Peptide or modification of the PNA backbone (at C5 or C2 carbon) with arginine side chains allows efficient cellular uptake. The present protocol describes the synthesis of cationic PNAs that can be used alone as drugs or for efficient co-delivery in suitable inorganic nanocarriers. |
Mendeley readers
The data shown below were compiled from readership statistics for 7 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 7 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 3 | 43% |
| Unspecified | 1 | 14% |
| Researcher | 1 | 14% |
| Student > Postgraduate | 1 | 14% |
| Unknown | 1 | 14% |
| Readers by discipline | Count | As % |
|---|---|---|
| Unspecified | 1 | 14% |
| Biochemistry, Genetics and Molecular Biology | 1 | 14% |
| Computer Science | 1 | 14% |
| Medicine and Dentistry | 1 | 14% |
| Neuroscience | 1 | 14% |
| Other | 1 | 14% |
| Unknown | 1 | 14% |