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Chapter title |
Highly Efficient SiRNA Delivery Mediated by Cationic Helical Polypeptides and Polypeptide-Based Nanosystems
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Chapter number | 4 |
Book title |
SiRNA Delivery Methods
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Published in |
Methods in molecular biology, January 2016
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DOI | 10.1007/978-1-4939-3112-5_4 |
Pubmed ID | |
Book ISBNs |
978-1-4939-3111-8, 978-1-4939-3112-5
|
Authors |
Lichen Yin, Nan Zheng, Jianjun Cheng, Yin, Lichen, Zheng, Nan, Cheng, Jianjun |
Abstract |
RNA interference (RNAi) mediated by small interfering RNA (SiRNA) has recently emerged as a potent machinery in regulating gene expression at the post-translation step. Despite its efficiency and specificity, the biggest hurdle against its wide application is the safe and effective delivery of the SiRNA cargo into target cells. Here, we describe the highly effective SiRNA delivery mediated by the cationic helical polypeptides and polypeptide-based nanosystems both in vitro and in vivo via oral administration. |
Mendeley readers
The data shown below were compiled from readership statistics for 5 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 5 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 2 | 40% |
Student > Ph. D. Student | 1 | 20% |
Unknown | 2 | 40% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 2 | 40% |
Chemistry | 1 | 20% |
Unknown | 2 | 40% |