Virus-Derived Nanoparticles for Advanced Technologies
Springer New York
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Mendeley readers
Attention Score in Context
| Chapter title |
Packaging DNA Origami into Viral Protein Cages
|
|---|---|
| Chapter number | 18 |
| Book title |
Virus-Derived Nanoparticles for Advanced Technologies
|
| Published in |
Methods in molecular biology, January 2018
|
| DOI | 10.1007/978-1-4939-7808-3_18 |
| Pubmed ID | |
| Book ISBNs |
978-1-4939-7806-9, 978-1-4939-7808-3
|
| Authors |
Veikko Linko, Joona Mikkilä, Mauri A. Kostiainen, Linko, Veikko, Mikkilä, Joona, Kostiainen, Mauri A. |
| Abstract |
The DNA origami technique is a widely used method to create customized, complex, spatially well-defined two-dimensional (2D) and three-dimensional (3D) DNA nanostructures. These structures have huge potential to serve as smart drug-delivery vehicles and molecular devices in various nanomedical and biotechnological applications. However, so far only little is known about the behavior of these novel structures in living organisms or in cell culture/tissue models. Moreover, enhancing pharmacokinetic bioavailability and transfection properties of such structures still remains a challenge. One intriguing approach to overcome these issues is to coat DNA origami nanostructures with proteins or lipid membranes. Here, we show how cowpea chlorotic mottle virus (CCMV) capsid proteins (CPs) can be used for coating DNA origami nanostructures. We present a method for disassembling native CCMV particles and isolating the pure CP dimers, which can further bind and encapsulate a rectangular DNA origami shape. Owing to the highly programmable nature of DNA origami, packaging of DNA nanostructures into viral protein cages could find imminent uses in enhanced targeting and cellular delivery of various active nano-objects, such as enzymes and drug molecules. |
X Demographics
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Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Finland | 1 | 50% |
| Estonia | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 50% |
| Scientists | 1 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 10 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 10 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 4 | 40% |
| Student > Master | 2 | 20% |
| Student > Bachelor | 1 | 10% |
| Unknown | 3 | 30% |
| Readers by discipline | Count | As % |
|---|---|---|
| Chemical Engineering | 2 | 20% |
| Biochemistry, Genetics and Molecular Biology | 1 | 10% |
| Physics and Astronomy | 1 | 10% |
| Social Sciences | 1 | 10% |
| Medicine and Dentistry | 1 | 10% |
| Other | 1 | 10% |
| Unknown | 3 | 30% |
Attention Score in Context
This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 31 October 2019.
All research outputs
#6,238,832
of 23,088,369 outputs
Outputs from Methods in molecular biology
#1,848
of 13,206 outputs
Outputs of similar age
#125,566
of 442,629 outputs
Outputs of similar age from Methods in molecular biology
#162
of 1,499 outputs
Altmetric has tracked 23,088,369 research outputs across all sources so far. This one has received more attention than most of these and is in the 72nd percentile.
So far Altmetric has tracked 13,206 research outputs from this source. They receive a mean Attention Score of 3.4. This one has done well, scoring higher than 85% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 442,629 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 71% of its contemporaries.
We're also able to compare this research output to 1,499 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 88% of its contemporaries.