| Chapter title |
The Role of Proteases in Pain
|
|---|---|
| Chapter number | 12 |
| Book title |
Pain Control
|
| Published in |
Handbook of experimental pharmacology, January 2015
|
| DOI | 10.1007/978-3-662-46450-2_12 |
| Pubmed ID | |
| Book ISBNs |
978-3-66-246449-6, 978-3-66-246450-2
|
| Authors |
Jason J. McDougall, Milind M. Muley, McDougall, Jason J., Muley, Milind M. |
| Abstract |
Proteinase-activated receptors (PARs) are a family of G protein-coupled receptor that are activated by extracellular cleavage of the receptor in the N-terminal domain. This slicing of the receptor exposes a tethered ligand which binds to a specific docking point on the receptor surface to initiate intracellular signalling. PARs are expressed by numerous tissues in the body, and they are involved in various physiological and pathological processes such as food digestion, tissue remodelling and blood coagulation. This chapter will summarise how serine proteinases activate PARs leading to the development of pain in several chronic pain conditions. The potential of PARs as a drug target for pain relief is also discussed. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 1 | 100% |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 19 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 3 | 16% |
| Student > Ph. D. Student | 3 | 16% |
| Other | 2 | 11% |
| Student > Bachelor | 2 | 11% |
| Student > Doctoral Student | 1 | 5% |
| Other | 2 | 11% |
| Unknown | 6 | 32% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 4 | 21% |
| Biochemistry, Genetics and Molecular Biology | 1 | 5% |
| Nursing and Health Professions | 1 | 5% |
| Pharmacology, Toxicology and Pharmaceutical Science | 1 | 5% |
| Computer Science | 1 | 5% |
| Other | 3 | 16% |
| Unknown | 8 | 42% |