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Intravital Imaging of Dynamic Bone and Immune Systems

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Cover of 'Intravital Imaging of Dynamic Bone and Immune Systems'

Table of Contents

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    Book Overview
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    Chapter 1 Bone Imaging: Osteoclast and Osteoblast Dynamics
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    Chapter 2 Intravital Imaging of Mouse Bone Marrow: Hemodynamics and Vascular Permeability
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    Chapter 3 Bone Imaging: Platelet Formation Dynamics
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    Chapter 4 Live Imaging of Interstitial T Cell Migration Using Lymph Node Slices
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    Chapter 5 Two-Photon Imaging of T-Cell Motility in Lymph Nodes: In Vivo and Ex Vivo Approaches
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    Chapter 6 Imaging the Lymph Node Stroma
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    Chapter 7 Intravital Imaging of B Cell Responses in Lymph Nodes
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    Chapter 8 Live Imaging of the Skin Immune Responses: Visualization of the Contact Hypersensitivity Response
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    Chapter 9 Imaging of Inflammatory Responses in the Mouse Ear Skin
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    Chapter 10 In Vivo Imaging of Immune Cells in Peyer’s Patches
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    Chapter 11 Intravital Imaging of T Cells Within the Spinal Cord
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    Chapter 12 Kidney Imaging: Intravital Microscopy
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    Chapter 13 Intravital Imaging of Liver Cell Dynamics
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    Chapter 14 Intravital Imaging of the Heart at the Cellular Level Using Two-Photon Microscopy
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    Chapter 15 Imaging Window Device for Subcutaneous Implantation Tumor
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    Chapter 16 New Tools for Imaging of Immune Systems: Visualization of Cell Cycle, Cell Death, and Cell Movement by Using the Mice Lines Expressing Fucci, SCAT3.1, and Kaede and KikGR
Attention for Chapter 1: Bone Imaging: Osteoclast and Osteoblast Dynamics
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Chapter title
Bone Imaging: Osteoclast and Osteoblast Dynamics
Chapter number 1
Book title
Intravital Imaging of Dynamic Bone and Immune Systems
Published by
Humana Press, New York, NY, February 2018
DOI 10.1007/978-1-4939-7762-8_1
Pubmed ID
Book ISBNs
978-1-4939-7761-1, 978-1-4939-7762-8
Authors

Junichi Kikuta, Masaru Ishii

Abstract

Bone is continually remodeled by bone-resorbing osteoclasts and bone-forming osteoblasts. Although it has long been believed that bone homeostasis is tightly regulated by communication between osteoclasts and osteoblasts, the fundamental process and dynamics have remained elusive. To resolve this, we established an intravital bone imaging system using multiphoton microscopy to visualize mature osteoclasts and osteoblasts in living bone.We herein describe the methodology for visualizing the in vivo behavior of bone-resorbing osteoclasts and bone-forming osteoblasts in living bone tissues using intravital multiphoton microscopy. This approach facilitates investigation of cellular dynamics in the pathogenesis of bone-destructive disorders, such as osteoporosis and rheumatoid arthritis in vivo, and would thus be useful for evaluating the efficacy of novel anti-bone-resorptive drugs.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 8 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 8 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 2 25%
Student > Master 1 13%
Student > Ph. D. Student 1 13%
Other 1 13%
Unknown 3 38%
Readers by discipline Count As %
Pharmacology, Toxicology and Pharmaceutical Science 1 13%
Biochemistry, Genetics and Molecular Biology 1 13%
Chemistry 1 13%
Medicine and Dentistry 1 13%
Engineering 1 13%
Other 0 0%
Unknown 3 38%