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Hemostasis and Thrombosis

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Cover of 'Hemostasis and Thrombosis'

Table of Contents

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    Book Overview
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    Chapter 1 Overview of Hemostasis and Thrombosis and Contribution of Laboratory Testing to Diagnosis and Management of Hemostasis and Thrombosis Disorders
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    Chapter 2 Preanalytical Issues in Hemostasis and Thrombosis Testing
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    Chapter 3 The Interface between Immunotransfusion and Hemostasis and Thrombosis Testing
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    Chapter 4 Optimizing the Verification of Mean Normal Prothrombin Time (MNPT) and International Sensitivity Index (ISI) for Accurate Conversion of Prothrombin Time (PT) to International Normalized Ratio (INR)
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    Chapter 5 Performance of Activated Partial Thromboplastin Time (APTT): Determining Reagent Sensitivity to Factor Deficiencies, Heparin, and Lupus Anticoagulants
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    Chapter 6 Performance and Interpretation of Mixing Tests in Coagulation
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    Chapter 7 D-Dimer Testing: Laboratory Aspects and Current Issues
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    Chapter 8 Determination of Fibrinogen and Thrombin Time (TT)
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    Chapter 9 An Overview of Thrombophilia and Associated Laboratory Testing
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    Chapter 10 Laboratory Testing for Activated Protein C Resistance (APCR)
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    Chapter 11 Assessment of Hereditary Thrombophilia: Performance of Protein C (PC) Testing
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    Chapter 12 Assessment of Hereditary Thrombophilia: Performance of Protein S (PS) Testing
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    Chapter 13 Assessment of Hereditary Thrombophilia: Performance of Antithrombin (AT) Testing
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    Chapter 14 Lupus Anticoagulant Testing: Diluted Russell Viper Venom Time (dRVVT)
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    Chapter 15 Lupus Anticoagulant Testing: Activated Partial Thromboplastin Time (APTT) and Silica Clotting Time (SCT)
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    Chapter 16 Solid Phase Immunoassay for the Detection of Anticardiolipin Antibodies
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    Chapter 17 Solid Phase Immunoassay for the Detection of Anti-β 2 Glycoprotein I Antibodies
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    Chapter 18 Measuring Direct Oral Anticoagulants
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    Chapter 19 Laboratory Testing Protocols for Heparin-Induced Thrombocytopenia (HIT) Testing
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    Chapter 20 One-Stage Factor VIII Assays
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    Chapter 21 Chromogenic Factor VIII Assays for Improved Diagnosis of Hemophilia A
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    Chapter 22 Assessment of Factor XIII
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    Chapter 23 Detection and Measurement of Factor Inhibitors
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    Chapter 24 Platelet Function Tests: Preanalytical Variables, Clinical Utility, Advantages, and Disadvantages
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    Chapter 25 Platelet Function Analyzed by Light Transmission Aggregometry
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    Chapter 26 Whole Blood Platelet Aggregometry
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    Chapter 27 Assessment of Platelet Function in Whole Blood by Flow Cytometry
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    Chapter 28 Flow Cytometry Protocols for Assessment of Platelet Function in Whole Blood
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    Chapter 29 Diagnosis or Exclusion of von Willebrand Disease Using Laboratory Testing
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    Chapter 30 Laboratory Testing for von Willebrand Factor Antigen (VWF:Ag)
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    Chapter 31 Laboratory Testing for von Willebrand Factor Collagen Binding (VWF:CB)
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    Chapter 32 Laboratory Testing for von Willebrand Factor Ristocetin Cofactor (VWF:RCo)
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    Chapter 33 Laboratory Testing for von Willebrand Factor Activity by Glycoprotein Ib Binding Assays (VWF:GPIb)
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    Chapter 34 Laboratory Testing for von Willebrand Factor: Factor VIII Binding (for 2N VWD)
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    Chapter 35 Ristocetin-Induced Platelet Aggregation (RIPA) and RIPA Mixing Studies
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    Chapter 36 Laboratory Testing for Von Willebrand Factor Multimers
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    Chapter 37 Thrombin Generation Assays (TGAs)
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    Chapter 38 The Overall Hemostatic Potential (OHP) Assay
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    Chapter 39 Thromboelastography (TEG)
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    Chapter 40 Post-analytical Issues in Hemostasis and Thrombosis Testing
Attention for Chapter 18: Measuring Direct Oral Anticoagulants
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Citations

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Chapter title
Measuring Direct Oral Anticoagulants
Chapter number 18
Book title
Hemostasis and Thrombosis
Published in
Methods in molecular biology, January 2017
DOI 10.1007/978-1-4939-7196-1_18
Pubmed ID
Book ISBNs
978-1-4939-7194-7, 978-1-4939-7196-1
Authors

Robert C. Gosselin, Jonathan Douxfils, Gosselin, Robert C., Douxfils, Jonathan

Abstract

Direct oral anticoagulants (DOACs) can be quantified using methods that can be performed in any clinical or research laboratory using manual or automated instrument platforms. Dabigatran etexilate, the oral direct thrombin inhibitor, can be quantified by drug-calibrated clot or chromogenic-based assays using either thrombin or ecarin as substrates. Oral direct anti-Xa inhibitors, such as rivaroxaban, apixaban, and edoxaban, can be quantified with drug-calibrated anti-Xa kits or reagents as typically used for measuring heparins (unfractionated, low molecular weight, or pentasaccharides).

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 16 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 16 100%

Demographic breakdown

Readers by professional status Count As %
Other 2 13%
Student > Bachelor 2 13%
Student > Master 2 13%
Researcher 2 13%
Student > Ph. D. Student 1 6%
Other 3 19%
Unknown 4 25%
Readers by discipline Count As %
Pharmacology, Toxicology and Pharmaceutical Science 4 25%
Biochemistry, Genetics and Molecular Biology 3 19%
Arts and Humanities 1 6%
Nursing and Health Professions 1 6%
Agricultural and Biological Sciences 1 6%
Other 1 6%
Unknown 5 31%