Chapter title |
Thrombin Generation Assays (TGAs)
|
---|---|
Chapter number | 37 |
Book title |
Hemostasis and Thrombosis
|
Published in |
Methods in molecular biology, January 2017
|
DOI | 10.1007/978-1-4939-7196-1_37 |
Pubmed ID | |
Book ISBNs |
978-1-4939-7194-7, 978-1-4939-7196-1
|
Authors |
Gian Luca Salvagno, Erik Berntorp, Salvagno, Gian Luca, Berntorp, Erik |
Abstract |
In recent years, there has been a revival of interest in a time-honored tool of the clotting trade: the thrombin generation curve or thrombin generation (TG) assay (TGA) as we now call it. Thrombin generation is a key coagulation process that determines the extent of a hemostatic plug or a thrombotic process. The recent development of newer tests based on the continuous registration of TG under in vitro conditions that mimic more closely what occurs in vivo prompted us to reinvestigate the balance between procoagulants and anticoagulants in patients. Measurement of TG is accepted as a research tool, but the variety of sources and concentrations of reagents, as well as technical constraints, limit its potential for proper clinical use. The newer TGAs not only provide an overall assessment of hemostasis but also provide promising laboratory tools for investigating hemorrhagic coagulopathies and monitoring replacement therapy in several clinical conditions. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 15 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Other | 3 | 20% |
Student > Bachelor | 2 | 13% |
Researcher | 2 | 13% |
Student > Postgraduate | 2 | 13% |
Professor | 1 | 7% |
Other | 2 | 13% |
Unknown | 3 | 20% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 7 | 47% |
Biochemistry, Genetics and Molecular Biology | 2 | 13% |
Agricultural and Biological Sciences | 2 | 13% |
Nursing and Health Professions | 1 | 7% |
Neuroscience | 1 | 7% |
Other | 0 | 0% |
Unknown | 2 | 13% |