| Chapter title |
The Aryl Hydrocarbon Receptor in Immunity: Tools and Potential.
|
|---|---|
| Chapter number | 16 |
| Book title |
Suppression and Regulation of Immune Responses
|
| Published in |
Methods in molecular biology, January 2016
|
| DOI | 10.1007/978-1-4939-3139-2_16 |
| Pubmed ID | |
| Book ISBNs |
978-1-4939-3138-5, 978-1-4939-3139-2
|
| Authors |
Esser, Charlotte, Charlotte Esser |
| Abstract |
The signaling pathway of the evolutionary old transcription factor AhR is inducible by a number of small molecular weight chemicals, including toxicants such as polycyclic aromatic hydrocarbons, bacterial toxic pigments, and physiological compounds such as tryptophan derivatives or dietary indoles. AhR activation is of immunological importance, but at the same time mediates toxicity of environmental pollutants, such as immunosuppression by dioxins. Measuring AhR activity and identification of ligands is thus of great interest for a variety of research fields. In this chapter, I briefly introduce the AhR signaling pathway, its role in immunology, and the tools and assays needed to analyze AhR signaling. Both are also needed when therapeutic applications are envisioned. |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 39 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Doctoral Student | 6 | 15% |
| Researcher | 6 | 15% |
| Student > Ph. D. Student | 5 | 13% |
| Student > Bachelor | 4 | 10% |
| Student > Master | 3 | 8% |
| Other | 3 | 8% |
| Unknown | 12 | 31% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 11 | 28% |
| Immunology and Microbiology | 4 | 10% |
| Medicine and Dentistry | 4 | 10% |
| Pharmacology, Toxicology and Pharmaceutical Science | 3 | 8% |
| Environmental Science | 1 | 3% |
| Other | 1 | 3% |
| Unknown | 15 | 38% |