| Chapter title |
Humanized Mice as Preclinical Models in Transplantation
|
|---|---|
| Chapter number | 11 |
| Book title |
Suppression and Regulation of Immune Responses
|
| Published in |
Methods in molecular biology, January 2016
|
| DOI | 10.1007/978-1-4939-3139-2_11 |
| Pubmed ID | |
| Book ISBNs |
978-1-4939-3138-5, 978-1-4939-3139-2
|
| Authors |
N. Safinia, P. D. Becker, T. Vaikunthanathan, F. Xiao, R. Lechler, G. Lombardi, Safinia, N., Becker, P. D., Vaikunthanathan, T., Xiao, F., Lechler, R., Lombardi, G. |
| Abstract |
Animal models have been instrumental in our understanding of the mechanisms of rejection and the testing of novel treatment options in the context of transplantation. We have now entered an exciting era with research on humanized mice driving advances in translational studies and in our understanding of the function of human cells in response to pathogens and cancer as well as the recognition of human allogeneic tissues in vivo. In this chapter we provide a historical overview of humanized mouse models of transplantation to date, outlining the distinct strains and share our experiences in the study of human transplantation immunology. |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Switzerland | 1 | 8% |
| Unknown | 11 | 92% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 4 | 33% |
| Student > Bachelor | 3 | 25% |
| Researcher | 2 | 17% |
| Student > Master | 1 | 8% |
| Professor > Associate Professor | 1 | 8% |
| Other | 0 | 0% |
| Unknown | 1 | 8% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 5 | 42% |
| Biochemistry, Genetics and Molecular Biology | 2 | 17% |
| Immunology and Microbiology | 2 | 17% |
| Nursing and Health Professions | 1 | 8% |
| Medicine and Dentistry | 1 | 8% |
| Other | 0 | 0% |
| Unknown | 1 | 8% |