Chapter title |
Corneal Immunosuppressive Mechanisms, Anterior Chamber-Associated Immune Deviation (ACAID) and Their Role in Allograft Rejection
|
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Chapter number | 13 |
Book title |
Suppression and Regulation of Immune Responses
|
Published in |
Methods in molecular biology, January 2016
|
DOI | 10.1007/978-1-4939-3139-2_13 |
Pubmed ID | |
Book ISBNs |
978-1-4939-3138-5, 978-1-4939-3139-2
|
Authors |
Oliver Treacy, Gerry Fahy, Thomas Ritter, Lisa O’Flynn, Treacy, Oliver, Fahy, Gerry, Ritter, Thomas, O’Flynn, Lisa |
Abstract |
Corneal transplantation is the most frequently performed transplant procedure in humans. Human leukocyte antigen matching, while imperative for other types of organ transplants, is usually not performed before cornea transplantation. With the use of topical steroid immunosuppressants, which are subsequently tailed off to almost zero, most corneal transplants will not be rejected in recipients with low risk of graft rejection. This phenomenon has been described as immune privilege by Medawar many years ago. However, this immune privilege is relative and can be easily eroded, e.g. by postoperative nonspecific inflammation or other causes of corneal or ocular inflammation. Interestingly, corneas that are at high risk of rejection have a higher failure rate than other organs. Considerable progress has been made in recent years to provide a better understanding of corneal immune privilege. This chapter will review current knowledge on ocular immunosuppressive mechanisms including anterior chamber-associated immune deviation and discuss their role(s) in corneal allograft rejection. Ultimately, this evolving information will be of benefit in developing therapeutic strategies to prevent corneal transplant rejection. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Germany | 1 | 13% |
Unknown | 7 | 88% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 4 | 50% |
Student > Postgraduate | 1 | 13% |
Student > Doctoral Student | 1 | 13% |
Student > Master | 1 | 13% |
Unknown | 1 | 13% |
Readers by discipline | Count | As % |
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Biochemistry, Genetics and Molecular Biology | 2 | 25% |
Veterinary Science and Veterinary Medicine | 1 | 13% |
Decision Sciences | 1 | 13% |
Engineering | 1 | 13% |
Other | 0 | 0% |
Unknown | 1 | 13% |