Chapter title |
Humoral Mediators of Remote Ischemic Conditioning: Important Role of eNOS/NO/Nitrite
|
---|---|
Chapter number | 8 |
Book title |
Brain Edema XVI
|
Published in |
Acta neurochirurgica Supplement, January 2016
|
DOI | 10.1007/978-3-319-18497-5_8 |
Pubmed ID | |
Book ISBNs |
978-3-31-918496-8, 978-3-31-918497-5
|
Authors |
David C. Hess, Mohammad Nasrul Hoda, Mohammad B. Khan, Hess, David C., Hoda, Mohammad Nasrul, Khan, Mohammad B. |
Abstract |
Remote ischemic conditioning (RIC) is a powerful cardioprotectant and neuroprotectant. The mechanism of protection likely involves circulating, blood-borne mediators that transmit the signal from the periphery to the brain. The neuroprotective effect of RIC may be partially related to improvements in cerebral blood flow (CBF). Nitrite is a key circulating mediator of RIC and may be a mediator of increased CBF and also mediate cytoprotection through its effects on nitrosylation of mitochondrial proteins such as complex I. Measuring plasma nitrite may serve as an important blood biomarker, and measuring CBF by techniques such as MRI arterial spin labeling (ASL) may be an ideal surrogate imaging biomarker in clinical trials of RIC. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 22 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 3 | 14% |
Student > Doctoral Student | 3 | 14% |
Student > Master | 2 | 9% |
Student > Ph. D. Student | 2 | 9% |
Lecturer | 1 | 5% |
Other | 4 | 18% |
Unknown | 7 | 32% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 4 | 18% |
Biochemistry, Genetics and Molecular Biology | 3 | 14% |
Neuroscience | 3 | 14% |
Agricultural and Biological Sciences | 1 | 5% |
Engineering | 1 | 5% |
Other | 0 | 0% |
Unknown | 10 | 45% |