Chapter title |
Toxicogenomics: A New Paradigm for Nanotoxicity Evaluation
|
---|---|
Chapter number | 9 |
Book title |
Cellular and Molecular Toxicology of Nanoparticles
|
Published in |
Advances in experimental medicine and biology, January 2018
|
DOI | 10.1007/978-3-319-72041-8_9 |
Pubmed ID | |
Book ISBNs |
978-3-31-972040-1, 978-3-31-972041-8
|
Authors |
Sourabh Dwivedi, Quaiser Saquib, Bilal Ahmad, Sabiha M. Ansari, Ameer Azam, Javed Musarrat, Dwivedi, Sourabh, Saquib, Quaiser, Ahmad, Bilal, Ansari, Sabiha M., Azam, Ameer, Musarrat, Javed |
Abstract |
The wider applications of nanoparticles (NPs) has evoked a world-wide concern due to their possible risk of toxicity in humans and other organisms. Aggregation and accumulation of NPs into cell leads to their interaction with biological macromolecules including proteins, nucleic acids and cellular organelles, which eventually induce toxicological effects. Application of toxicogenomics to investigate molecular pathway-based toxicological consequences has opened new vistas in nanotoxicology research. Indeed, genomic approaches appeared as a new paradigm in terms of providing information at molecular levels and have been proven to be as a powerful tool for identification and quantification of global shifts in gene expression. Toxicological responses of NPs have been discussed in this chapter with the aim to provide a clear understanding of the molecular mechanism of NPs induced toxicity both in in vivo and in vitro test models. |
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Country | Count | As % |
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Unknown | 3 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 3 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 23 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 6 | 26% |
Other | 4 | 17% |
Researcher | 2 | 9% |
Student > Doctoral Student | 1 | 4% |
Student > Bachelor | 1 | 4% |
Other | 5 | 22% |
Unknown | 4 | 17% |
Readers by discipline | Count | As % |
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Agricultural and Biological Sciences | 6 | 26% |
Immunology and Microbiology | 3 | 13% |
Biochemistry, Genetics and Molecular Biology | 2 | 9% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 4% |
Psychology | 1 | 4% |
Other | 4 | 17% |
Unknown | 6 | 26% |