Cellular and Molecular Toxicology of Nanoparticles

Mariusz Zuberek, Agnieszka Grzelak, Zuberek, Mariusz, Grzelak, Agnieszka

Application of nanomaterials in nearly every single branch of industry results in their accumulation in both abiotic environment and tissues of living organisms. Despite the common use of nanomaterials, we are not able to precisely define their toxicity towards humans and surrounding biota. Although we were able to determine final effects of chronic exposure to nanoparticles which consist of many pathologies such as respiratory diseases, allergies, diseases of cardiovascular system, disorders in embryonic life differentiation and growth disorders, toxic effects on the immune system and cancers. The most predominantly investigated feature of most nanoparticles is their ability to induce oxidative stress on cellular level. Imbalance in redox state of cells can lead to various malfunctions in their internal metabolism, which in turn can lead to mentioned pathologies on the organismal level if the exposure is persistent and spread wide enough. Imbalance in redox state translate into production of reactive oxygen species in amounts impossible to be scavenged in given time. Many reactive oxygen species play crucial role in physiological processes in properly functioning cells. It was proven on numerous occasions that abundance of ROS, aside from oxidative damage, can lead to more subtle adverse effects tied to disturbances in intra- and intercellular signaling pathways. In this chapter we would like to address the nanoparticle-induced redox imbalance in cells and its effects.