Cellular and Molecular Toxicology of Nanoparticles

S. Aurosman Pappus, Monalisa Mishra, Pappus, S. Aurosman, Mishra, Monalisa

In recent era, nanoparticles (NPs) are widely used in food, medicine and body implants. Besides it's wide use being a foreign particle it may have some noxious effect on the body. To understand the mechanistic role of NPs toxicity, Drosophila appeared to be a superior model organism. Toxicity of several nanoparticles were accessed using Drosophila. The NPs, after oral route of exposure enter into the gut, crosses the barrier of peritrophic membrane and induces apoptosis. The toxicity of NPs within gut resulted in developmental delay, with decrease in pupa count, fly hatching along with weight loss. The adult fly hatched after nanoparticle treatment shows increasing phenotypic defect in various sensory organs as well as in different body parts. Besides phenotypic defect some of the nanoparticle results altered behavioural phenotypes like larva crawling or adult climbing. Alteration of both phenotypic as well as behavioural assay clearly hints that signalling pathway like Notch, Wnt, EGFR etc. get affected due to exposure of nanoparticle. Results from various labs prove that nanoparticle can mediate developmental defect by altering signalling pathways. Since many of the signalling pathways are conserved the effect seen in model organisms cannot be overlooked. All the nanoparticles used in food and medicine should be modified to nullify the toxic effect before used in food and medicine.