Chapter title |
Pathophysiological Mechanisms and Correlates of Therapeutic Pharmacological Interventions in Essential Arterial Hypertension
|
---|---|
Chapter number | 169 |
Book title |
Hypertension: from basic research to clinical practice
|
Published in |
Advances in experimental medicine and biology, January 2016
|
DOI | 10.1007/5584_2016_169 |
Pubmed ID | |
Book ISBNs |
978-3-31-944250-1, 978-3-31-944251-8
|
Authors |
Francesco Maranta, Roberto Spoladore, Gabriele Fragasso |
Abstract |
Treating arterial hypertension (HT) remains a hard task. The hypertensive patient is often a subject with several comorbidities and metabolic abnormalities. Clinicians everyday have to choose the right drug for the single patient among the different classes of antihypertensives. Apart from lowering blood pressure, a main therapeutic target should be that of counteracting all the possible pathophysiological mechanisms involved in HT itself and in existing/potential comorbidities. All the ancillary positive and negative effects of the administered drugs should be considered: in particular, since hypertensive patients are often glucose intolerant/diabetic, carrier of serum lipids disorder, have already developed atherosclerotic diseases and endothelial dysfunction, they should not be treated with drugs negatively interfering with these conditions but with molecules that, if possible, improve them. The main pathophysiological mechanisms and correlates of therapeutic pharmacological interventions in essential HT are reviewed here. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 29 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 4 | 14% |
Student > Master | 4 | 14% |
Student > Bachelor | 3 | 10% |
Student > Doctoral Student | 3 | 10% |
Student > Ph. D. Student | 2 | 7% |
Other | 3 | 10% |
Unknown | 10 | 34% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 9 | 31% |
Pharmacology, Toxicology and Pharmaceutical Science | 4 | 14% |
Biochemistry, Genetics and Molecular Biology | 2 | 7% |
Nursing and Health Professions | 2 | 7% |
Business, Management and Accounting | 1 | 3% |
Other | 2 | 7% |
Unknown | 9 | 31% |