Chapter title |
Novel Pathophysiological Mechanisms in Hypertension
|
---|---|
Chapter number | 96 |
Book title |
Hypertension: from basic research to clinical practice
|
Published in |
Advances in experimental medicine and biology, January 2016
|
DOI | 10.1007/5584_2016_96 |
Pubmed ID | |
Book ISBNs |
978-3-31-944250-1, 978-3-31-944251-8
|
Authors |
Rohan Samson, Andrew Lee, Sean Lawless, Robert Hsu, Gary Sander |
Abstract |
Hypertension is the most common disease affecting humans and imparts a significant cardiovascular and renal risk to patients. Extensive research over the past few decades has enhanced our understanding of the underlying mechanisms in hypertension. However, in most instances, the cause of hypertension in a given patient continues to remain elusive. Nevertheless, achieving aggressive blood pressure goals significantly reduces cardiovascular morbidity and mortality, as demonstrated in the recently concluded SPRINT trial. Since a large proportion of patients still fail to achieve blood pressure goals, knowledge of novel pathophysiologic mechanisms and mechanism based treatment strategies is crucial. The following chapter will review the novel pathophysiological mechanisms in hypertension, with a focus on role of immunity, inflammation and vascular endothelial homeostasis. The therapeutic implications of these mechanisms will be discussed where applicable. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 12 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 2 | 17% |
Student > Postgraduate | 2 | 17% |
Student > Ph. D. Student | 1 | 8% |
Student > Doctoral Student | 1 | 8% |
Professor > Associate Professor | 1 | 8% |
Other | 1 | 8% |
Unknown | 4 | 33% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 3 | 25% |
Nursing and Health Professions | 2 | 17% |
Chemistry | 1 | 8% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 8% |
Unknown | 5 | 42% |