Chapter title |
Mitochondrial-Associated Membranes in Parkinson’s Disease
|
---|---|
Chapter number | 12 |
Book title |
Organelle Contact Sites
|
Published in |
Advances in experimental medicine and biology, January 2017
|
DOI | 10.1007/978-981-10-4567-7_12 |
Pubmed ID | |
Book ISBNs |
978-9-81-104566-0, 978-9-81-104567-7
|
Authors |
Nobutaka Hattori, Taku Arano, Taku Hatano, Akio Mori, Yuzuru Imai, Hattori, Nobutaka, Arano, Taku, Hatano, Taku, Mori, Akio, Imai, Yuzuru |
Abstract |
Parkinson's disease (PD) is a common neurodegenerative disorder, with ageing being a major risk factor. Accordingly, estimates predict an increasing number of PD patients due to our expanding life span. Consequently, developing a true disease-modifying therapy is necessary. In this regard, monogenic PD offers a suitable means for determining pathogenesis. Among monogenic forms of PD, mitochondrial dysfunction may be a major cause and is also likely to be involved in sporadic PD. Thus, mitochondrial impairment may be a common pathway. Recently, mitochondria-associated membranes (MAM) were identified as dynamic sites between mitochondria and endoplasmic reticulum. Indeed, the gene product of α-synuclein is a major component of MAM, with other gene products also involved. This review focuses on the possibility of using MAM as novel therapeutic targets. |
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