Chapter title |
Regulation of Mitochondrial Dynamics and Autophagy by the Mitochondria-Associated Membrane
|
---|---|
Chapter number | 3 |
Book title |
Organelle Contact Sites
|
Published in |
Advances in experimental medicine and biology, January 2017
|
DOI | 10.1007/978-981-10-4567-7_3 |
Pubmed ID | |
Book ISBNs |
978-9-81-104566-0, 978-9-81-104567-7
|
Authors |
Mitsuo Tagaya, Kohei Arasaki, Tagaya, Mitsuo, Arasaki, Kohei |
Abstract |
Mitochondria are powerhouses and central to metabolism in cells. They are highly dynamic organelles that continuously fuse, divide, and move along the cytoskeleton to form the mitochondrial network. The fusion and fission are catalyzed by four dynamin-related GTPases in mammals that are controlled by a variety of protein-protein interactions and posttranslational modifications. Mitochondrial dynamics and metabolism are linked and regulate each other. Starvation induces mitochondrial elongation, which enables the mitochondria to produce energy more efficiently and to escape from autophagic degradation. Damaged portions of mitochondria are removed from the healthy parts by division, and subsequently degraded via a specific mode of autophagy termed mitophagy. Recent studies shed light on the contribution of the endoplasmic reticulum to mitochondrial dynamics and the cooperation of the two organelles for the progression of autophagy including mitophagy. A subdomain of the endoplasmic reticulum apposed to mitochondria is called the mitochondria-associated membrane (MAM), which comprises a unique set of proteins that interact with mitochondrial proteins. Here we review our current understanding of the molecular mechanisms of mitochondrial dynamics and mitochondria-related processes in the context of the interaction with the endoplasmic reticulum. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 33% |
Unknown | 2 | 67% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 3 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 57 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 17 | 30% |
Student > Bachelor | 6 | 11% |
Researcher | 5 | 9% |
Student > Master | 5 | 9% |
Student > Doctoral Student | 3 | 5% |
Other | 8 | 14% |
Unknown | 13 | 23% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 21 | 37% |
Neuroscience | 8 | 14% |
Agricultural and Biological Sciences | 7 | 12% |
Medicine and Dentistry | 3 | 5% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 2% |
Other | 1 | 2% |
Unknown | 16 | 28% |