Chapter title |
Hepatitis C Virus Replication
|
---|---|
Chapter number | 15 |
Book title |
Organelle Contact Sites
|
Published in |
Advances in experimental medicine and biology, January 2017
|
DOI | 10.1007/978-981-10-4567-7_15 |
Pubmed ID | |
Book ISBNs |
978-9-81-104566-0, 978-9-81-104567-7
|
Authors |
Tetsuro Suzuki, Suzuki, Tetsuro |
Abstract |
Viruses use synthetic mechanism and organelles of the host cells to facilitate their replication and make new viruses. Host's ATP provides necessary energy. Hepatitis C virus (HCV) is a major cause of liver disease. Like other positive-strand RNA viruses, the HCV genome is thought to be synthesized by the replication complex, which consists of viral- and host cell-derived factors, in tight association with structurally rearranged vesicle-like cytoplasmic membranes. The virus-induced remodeling of subcellular membranes, which protect the viral RNA from nucleases in the cytoplasm, promotes efficient replication of HCV genome. The assembly of HCV particle involves interactions between viral structural and nonstructural proteins and pathways related to lipid metabolisms in a concerted fashion. Association of viral core protein, which forms the capsid, with lipid droplets appears to be a prerequisite for early steps of the assembly, which are closely linked with the viral genome replication. This review presents the recent progress in understanding the mechanisms for replication and assembly of HCV through its interactions with organelles or distinct organelle-like structures. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Gambia | 1 | <1% |
Brazil | 1 | <1% |
Unknown | 99 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 19 | 19% |
Student > Bachelor | 17 | 17% |
Researcher | 15 | 15% |
Student > Master | 14 | 14% |
Student > Doctoral Student | 6 | 6% |
Other | 12 | 12% |
Unknown | 18 | 18% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 19 | 19% |
Biochemistry, Genetics and Molecular Biology | 17 | 17% |
Agricultural and Biological Sciences | 16 | 16% |
Immunology and Microbiology | 14 | 14% |
Chemistry | 4 | 4% |
Other | 10 | 10% |
Unknown | 21 | 21% |