Chapter title |
Over Six Decades of Discovery and Characterization of the Architecture at Mitochondria-Associated Membranes (MAMs)
|
---|---|
Chapter number | 2 |
Book title |
Organelle Contact Sites
|
Published in |
Advances in experimental medicine and biology, January 2017
|
DOI | 10.1007/978-981-10-4567-7_2 |
Pubmed ID | |
Book ISBNs |
978-9-81-104566-0, 978-9-81-104567-7
|
Authors |
Maria Sol Herrera-Cruz, Thomas Simmen, Herrera-Cruz, Maria Sol, Simmen, Thomas |
Abstract |
The discovery of proteins regulating ER-mitochondria tethering including phosphofurin acidic cluster sorting protein 2 (PACS-2) and mitofusin-2 has pushed contact sites between the endoplasmic reticulum (ER) and mitochondria into the spotlight of cell biology. While the field is developing rapidly and controversies have come and gone multiple times during its history, it is sometimes overlooked that significant research has been done decades ago with the original discovery of these structures in the 1950s and the first characterization of their function (and coining of the term mitochondria-associated membrane, MAM) in 1990. Today, an ever-increasing array of proteins localize to the MAM fraction of the endoplasmic reticulum (ER) to regulate the interaction of this organelle with mitochondria. These mitochondria-ER contacts, sometimes referred to as MERCs, regulate a multitude of biological functions, including lipid metabolism, Ca(2+) signaling, bioenergetics, inflammation, autophagy, mitochondrial structure, and apoptosis. |
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Geographical breakdown
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United States | 1 | 33% |
Unknown | 2 | 67% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 3 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 53 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 9 | 17% |
Student > Doctoral Student | 8 | 15% |
Student > Master | 8 | 15% |
Researcher | 4 | 8% |
Student > Postgraduate | 3 | 6% |
Other | 3 | 6% |
Unknown | 18 | 34% |
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Medicine and Dentistry | 4 | 8% |
Agricultural and Biological Sciences | 3 | 6% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 4% |
Other | 3 | 6% |
Unknown | 18 | 34% |