| Chapter title |
Role of Endoplasmic Reticulum-Mitochondria Communication in Type 2 Diabetes
|
|---|---|
| Chapter number | 13 |
| Book title |
Organelle Contact Sites
|
| Published in |
Advances in experimental medicine and biology, January 2017
|
| DOI | 10.1007/978-981-10-4567-7_13 |
| Pubmed ID | |
| Book ISBNs |
978-9-81-104566-0, 978-9-81-104567-7
|
| Authors |
Jennifer Rieusset, Rieusset, Jennifer |
| Abstract |
Although mitochondrial dysfunction, endoplasmic reticulum (ER) stress, and disrupted lipid and calcium (Ca(2+)) homeostasis are classically associated with both insulin resistance and β-cell dysfunction in type 2 diabetes mellitus (T2DM), the interplay between these metabolic stresses is less known. Both organelles interact through contact points known as mitochondria-associated membranes (MAM), in order to exchange both lipids and Ca(2+) and regulate cellular homeostasis. Recent evidences suggest that MAM could be an important hub for hormonal and nutrient signaling in the liver and that ER-mitochondria miscommunication could participate to hepatic insulin resistance, highlighting the importance of MAM in the control of glucose homeostasis. Here, we specifically discuss the role of MAM in hormonal and nutrient-regulated signaling pathways supporting a role in the control of glucose homeostasis and analyze the evidences pointing a role of ER-mitochondria miscommunication in T2DM. Collectively, these data suggest that targeting MAM structure and function might be a novel strategy for the treatment of T2DM. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 55 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 14 | 25% |
| Student > Bachelor | 7 | 13% |
| Researcher | 5 | 9% |
| Student > Master | 5 | 9% |
| Student > Postgraduate | 3 | 5% |
| Other | 8 | 15% |
| Unknown | 13 | 24% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 18 | 33% |
| Medicine and Dentistry | 5 | 9% |
| Agricultural and Biological Sciences | 5 | 9% |
| Nursing and Health Professions | 3 | 5% |
| Social Sciences | 3 | 5% |
| Other | 6 | 11% |
| Unknown | 15 | 27% |