Chapter title |
Long Noncoding RNAs in Mammalian Development and Diseases
|
---|---|
Chapter number | 6 |
Book title |
Long Non Coding RNA Biology
|
Published in |
Advances in experimental medicine and biology, January 2017
|
DOI | 10.1007/978-981-10-5203-3_6 |
Pubmed ID | |
Book ISBNs |
978-9-81-105202-6, 978-9-81-105203-3
|
Authors |
Parna Saha, Shreekant Verma, Rashmi U. Pathak, Rakesh K. Mishra |
Abstract |
Following analysis of sequenced genomes and transcriptome of many eukaryotes, it is evident that virtually all protein-coding genes have already been discovered. These advances have highlighted an intriguing paradox whereby the relative amount of protein-coding sequences remain constant but nonprotein-coding sequences increase consistently in parallel to increasing evolutionary complexity. It is established that differences between species map to nonprotein-coding regions of the genome that surprisingly is transcribed extensively. These transcripts regulate epigenetic processes and constitute an important layer of regulatory information essential for organismal development and play a causative role in diseases. The noncoding RNA-directed regulatory circuit controls complex characteristics. Sequence variations in noncoding RNAs influence evolution, quantitative traits, and disease susceptibility. This chapter presents an account on a class of such noncoding transcripts that are longer than 200 nucleotides (long noncoding RNA-lncRNA) in mammalian development and diseases. |
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Demographic breakdown
Type | Count | As % |
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Members of the public | 3 | 100% |
Mendeley readers
Geographical breakdown
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Student > Ph. D. Student | 5 | 31% |
Student > Doctoral Student | 2 | 13% |
Researcher | 2 | 13% |
Professor | 1 | 6% |
Other | 1 | 6% |
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Unknown | 4 | 25% |
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Unknown | 3 | 19% |