Chapter title |
Ultrasound Imaging of DNA-Damage Effects in Live Cultured Cells and in Brain Tissue
|
---|---|
Chapter number | 3 |
Book title |
Fast Detection of DNA Damage
|
Published in |
Methods in molecular biology, July 2017
|
DOI | 10.1007/978-1-4939-7187-9_3 |
Pubmed ID | |
Book ISBNs |
978-1-4939-7185-5, 978-1-4939-7187-9
|
Authors |
Hadi Tadayyon, Mehrdad J. Gangeh, Roxana Vlad, Michael C. Kolios, Gregory J. Czarnota |
Abstract |
High-frequency ultrasound (>20 MHz) spectroscopy can be used to detect noninvasively DNA damage in cell samples in vitro, and in live tissue both ex vivo and in vivo. This chapter focuses on the former two aspects. Experimental evidence suggests that morphological changes that occur in cells undergoing apoptosis result in changes in frequency-dependent ultrasound backscatter. With advances in research, ultrasound spectroscopy is advancing the boundaries of fast, label-free, noninvasive DNA damage detection technology with potential use in personalized medicine and early therapy response monitoring. Depending on the desired resolution, parametric ultrasound images can be computed and displayed within minutes to hours after ultrasound examination for cell death. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 9 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 2 | 22% |
Student > Bachelor | 1 | 11% |
Student > Ph. D. Student | 1 | 11% |
Professor | 1 | 11% |
Student > Master | 1 | 11% |
Other | 1 | 11% |
Unknown | 2 | 22% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 3 | 33% |
Physics and Astronomy | 1 | 11% |
Psychology | 1 | 11% |
Unknown | 4 | 44% |