| Chapter title |
Drug Addiction and DNA Modifications
|
|---|---|
| Chapter number | 6 |
| Book title |
Neuroepigenomics in Aging and Disease
|
| Published in |
Advances in experimental medicine and biology, May 2017
|
| DOI | 10.1007/978-3-319-53889-1_6 |
| Pubmed ID | |
| Book ISBNs |
978-3-31-953888-4, 978-3-31-953889-1
|
| Authors |
Brown, Amber N., Feng, Jian, Amber N. Brown, Jian Feng |
| Editors |
Raul Delgado-Morales |
| Abstract |
Drug addiction is a complex disorder which can be influenced by both genetic and environmental factors. Research has shown that epigenetic modifications can translate environmental signals into changes in gene expression, suggesting that epigenetic changes may underlie the causes and possibly treatment of substance use disorders. This chapter will focus on epigenetic modifications to DNA, which include DNA methylation and several recently defined additional DNA epigenetic changes. We will discuss the functions of DNA modifications and methods for detecting them, followed by a description of the research investigating the function and consequences of drug-induced changes in DNA methylation patterns. Understanding these epigenetic changes may provide us translational tools for the diagnosis and treatment of addiction in the future. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| France | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 54 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 8 | 15% |
| Student > Master | 7 | 13% |
| Researcher | 6 | 11% |
| Student > Bachelor | 5 | 9% |
| Student > Doctoral Student | 3 | 6% |
| Other | 7 | 13% |
| Unknown | 18 | 33% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 8 | 15% |
| Biochemistry, Genetics and Molecular Biology | 7 | 13% |
| Neuroscience | 7 | 13% |
| Agricultural and Biological Sciences | 3 | 6% |
| Pharmacology, Toxicology and Pharmaceutical Science | 2 | 4% |
| Other | 5 | 9% |
| Unknown | 22 | 41% |