Chapter title |
Drug Addiction and Histone Code Alterations
|
---|---|
Chapter number | 7 |
Book title |
Neuroepigenomics in Aging and Disease
|
Published in |
Advances in experimental medicine and biology, May 2017
|
DOI | 10.1007/978-3-319-53889-1_7 |
Pubmed ID | |
Book ISBNs |
978-3-31-953888-4, 978-3-31-953889-1
|
Authors |
Kim, Hee-Dae, Call, Tanessa, Magazu, Samantha, Ferguson, Deveroux, Hee-Dae Kim Ph.D., Tanessa Call B.A., Samantha Magazu M.S., Deveroux Ferguson Ph.D., Hee-Dae Kim, Tanessa Call, Samantha Magazu, Deveroux Ferguson |
Editors |
Raul Delgado-Morales |
Abstract |
Acute and prolonged exposure to drugs of abuse induces changes in gene expression, synaptic function, and neural plasticity in brain regions involved in reward. Numerous genes are involved in this process, and persistent changes in gene expression coincide with epigenetic histone modifications and DNA methylation. Histone modifications are attractive regulatory mechanisms, which can encode complex environmental signals in the genome of postmitotic cells, like neurons. Recently, it has been demonstrated that specific histone modifications are involved in addiction-related gene regulatory mechanisms, by a diverse set of histone-modifying enzymes and readers. These histone modifiers and readers may prove to be valuable pharmacological targets for effective treatments for drug addiction. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 1 | 25% |
France | 1 | 25% |
Unknown | 2 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 3 | 75% |
Practitioners (doctors, other healthcare professionals) | 1 | 25% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 15 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Bachelor | 3 | 20% |
Student > Master | 3 | 20% |
Student > Ph. D. Student | 2 | 13% |
Student > Doctoral Student | 1 | 7% |
Researcher | 1 | 7% |
Other | 1 | 7% |
Unknown | 4 | 27% |
Readers by discipline | Count | As % |
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Neuroscience | 4 | 27% |
Biochemistry, Genetics and Molecular Biology | 2 | 13% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 7% |
Social Sciences | 1 | 7% |
Immunology and Microbiology | 1 | 7% |
Other | 0 | 0% |
Unknown | 6 | 40% |