Chapter title |
Alzheimer’s Disease and ncRNAs
|
---|---|
Chapter number | 18 |
Book title |
Neuroepigenomics in Aging and Disease
|
Published in |
Advances in experimental medicine and biology, May 2017
|
DOI | 10.1007/978-3-319-53889-1_18 |
Pubmed ID | |
Book ISBNs |
978-3-31-953888-4, 978-3-31-953889-1
|
Authors |
Maoz, Rotem, Garfinkel, Benjamin P., Soreq, Hermona, Rotem Maoz B.Sc., Benjamin P. Garfinkel Ph.D., Hermona Soreq Ph.D., Rotem Maoz, Benjamin P. Garfinkel, Hermona Soreq |
Editors |
Raul Delgado-Morales |
Abstract |
Alzheimer's disease is a devastating neurodegenerative disorder affecting a significant portion of the world's rapidly growing aging population. In spite of its prevalence, the etiology of the disease is still poorly understood, and effective therapy is all but unavailable. Over the past decade, noncoding RNA, including microRNA (miRNA), has emerged as a major class of regulatory molecules involved in virtually all physiological and disease states. The specificity provided by miRNA sequence complementarity, together with the ability of these molecules to regulate complex networks of genes, has made them exciting novel targets for therapeutic agents. In this chapter, we review recent progress on understanding the role of noncoding RNA in Alzheimer's disease (AD). The majority of available work has focused on miRNA, and we review the many studies implicating specific miRNAs in the development of the disease. More recently, several studies have tied other RNA classes to the disorder, including long noncoding RNA, circular RNA, and Y RNAs, and we review this fascinating field as well. Finally, we explore the potential promise of these findings for future therapeutic applications. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 2 | 67% |
Unknown | 1 | 33% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 3 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 73 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 13 | 18% |
Student > Ph. D. Student | 12 | 16% |
Researcher | 7 | 10% |
Student > Postgraduate | 6 | 8% |
Student > Master | 5 | 7% |
Other | 10 | 14% |
Unknown | 20 | 27% |
Readers by discipline | Count | As % |
---|---|---|
Neuroscience | 16 | 22% |
Biochemistry, Genetics and Molecular Biology | 15 | 21% |
Medicine and Dentistry | 6 | 8% |
Agricultural and Biological Sciences | 5 | 7% |
Pharmacology, Toxicology and Pharmaceutical Science | 4 | 5% |
Other | 5 | 7% |
Unknown | 22 | 30% |