| Chapter title |
Epigenetics in Parkinson’s Disease
|
|---|---|
| Chapter number | 19 |
| Book title |
Neuroepigenomics in Aging and Disease
|
| Published in |
Advances in experimental medicine and biology, May 2017
|
| DOI | 10.1007/978-3-319-53889-1_19 |
| Pubmed ID | |
| Book ISBNs |
978-3-31-953888-4, 978-3-31-953889-1, 978-3-31-953888-4, 978-3-31-953889-1
|
| Authors |
Pavlou, Maria Angeliki S., Outeiro, Tiago Fleming, Maria Angeliki S. Pavlou B.Sc., M.Sc., Ph.D., Tiago Fleming Outeiro B.Sc., M.Sc., Ph.D., Maria Angeliki S. Pavlou, Tiago Fleming Outeiro |
| Editors |
Raul Delgado-Morales |
| Abstract |
Parkinson's disease (PD) is a highly complex neurodegenerative disorder with a multifactorial origin. Although several cellular mechanisms and genes have been implicated in the onset and progression of the disease, the precise molecular underpinnings of the disease remain unclear. In this context, epigenetic modulation of gene expression by environmental factors is emerging as an important mechanism in PD and in other neurodegenerative disorders. Thus, epigenetic mechanisms, such as DNA methylation, histone modifications and altered microRNA expression, have been under intense investigation due to their possible involvement in PD. Epigenetic modulation is responsible for inducing differential gene expression, a phenomenon which is essential throughout life in order to regulate multiple cellular responses such as development, cellular fate commitment and adaptation to the environment. Disturbances of a balanced gene expression can, therefore, have detrimental effects. Environmental factors can challenge the establishment and maintenance of epigenetic modifications and could thereby fill the gap in our further understanding of origin and/or progression of neurodegenerative diseases. In this chapter, we focus on the role of epigenetics in PD. |
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| Unknown | 3 | 50% |
Demographic breakdown
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| Members of the public | 5 | 83% |
| Scientists | 1 | 17% |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 134 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 29 | 22% |
| Student > Master | 19 | 14% |
| Student > Ph. D. Student | 13 | 10% |
| Researcher | 7 | 5% |
| Student > Doctoral Student | 4 | 3% |
| Other | 11 | 8% |
| Unknown | 51 | 38% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 26 | 19% |
| Neuroscience | 19 | 14% |
| Medicine and Dentistry | 10 | 7% |
| Agricultural and Biological Sciences | 8 | 6% |
| Pharmacology, Toxicology and Pharmaceutical Science | 4 | 3% |
| Other | 9 | 7% |
| Unknown | 58 | 43% |