| Chapter title |
Epigenetics of Autism Spectrum Disorder
|
|---|---|
| Chapter number | 4 |
| Book title |
Neuroepigenomics in Aging and Disease
|
| Published in |
Advances in experimental medicine and biology, May 2017
|
| DOI | 10.1007/978-3-319-53889-1_4 |
| Pubmed ID | |
| Book ISBNs |
978-3-31-953888-4, 978-3-31-953889-1
|
| Authors |
Siu, Michelle T., Weksberg, Rosanna, Michelle T. Siu Ph.D., Rosanna Weksberg M.D., Ph.D., Michelle T. Siu, Rosanna Weksberg |
| Editors |
Raul Delgado-Morales |
| Abstract |
Autism spectrum disorder (ASD), one of the most common childhood neurodevelopmental disorders (NDDs), is diagnosed in 1 of every 68 children. ASD is incredibly heterogeneous both clinically and aetiologically. The etiopathogenesis of ASD is known to be complex, including genetic, environmental and epigenetic factors. Normal epigenetic marks modifiable by both genetics and environmental exposures can result in epigenetic alterations that disrupt the regulation of gene expression, negatively impacting biological pathways important for brain development. In this chapter we aim to summarize some of the important literature that supports a role for epigenetics in the underlying molecular mechanism of ASD. We provide evidence from work in genetics, from environmental exposures and finally from more recent studies aimed at directly determining ASD-specific epigenetic patterns, focusing mainly on DNA methylation (DNAm). Finally, we briefly discuss some of the implications of current research on potential epigenetic targets for therapeutics and novel avenues for future work. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Mexico | 2 | 8% |
| Spain | 2 | 8% |
| France | 2 | 8% |
| Canada | 2 | 8% |
| Tuvalu | 1 | 4% |
| Chile | 1 | 4% |
| United States | 1 | 4% |
| Italy | 1 | 4% |
| Germany | 1 | 4% |
| Other | 2 | 8% |
| Unknown | 9 | 38% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 19 | 79% |
| Scientists | 3 | 13% |
| Practitioners (doctors, other healthcare professionals) | 2 | 8% |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | <1% |
| Germany | 1 | <1% |
| Unknown | 150 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 28 | 18% |
| Researcher | 20 | 13% |
| Student > Ph. D. Student | 14 | 9% |
| Student > Doctoral Student | 13 | 9% |
| Student > Master | 12 | 8% |
| Other | 20 | 13% |
| Unknown | 45 | 30% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 25 | 16% |
| Biochemistry, Genetics and Molecular Biology | 21 | 14% |
| Psychology | 16 | 11% |
| Neuroscience | 10 | 7% |
| Agricultural and Biological Sciences | 9 | 6% |
| Other | 19 | 13% |
| Unknown | 52 | 34% |