| Chapter title |
Single-Cell Genomics Unravels Brain Cell-Type Complexity
|
|---|---|
| Chapter number | 20 |
| Book title |
Neuroepigenomics in Aging and Disease
|
| Published in |
Advances in experimental medicine and biology, May 2017
|
| DOI | 10.1007/978-3-319-53889-1_20 |
| Pubmed ID | |
| Book ISBNs |
978-3-31-953888-4, 978-3-31-953889-1
|
| Authors |
Guillaumet-Adkins, Amy, Heyn, Holger, Amy Guillaumet-Adkins Ph.D., Holger Heyn Ph.D., Amy Guillaumet-Adkins, Holger Heyn |
| Editors |
Raul Delgado-Morales |
| Abstract |
The brain is the most complex tissue in terms of cell types that it comprises, to the extent that it is still poorly understood. Single cell genome and transcriptome profiling allow to disentangle the neuronal heterogeneity, enabling the categorization of individual neurons into groups with similar molecular signatures. Herein, we unravel the current state of knowledge in single cell neurogenomics. We describe the molecular understanding of the cellular architecture of the mammalian nervous system in health and in disease; from the discovery of unrecognized cell types to the validation of known ones, applying these state-of-the-art technologies. |
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|---|---|---|
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| United States | 1 | 25% |
| Unknown | 2 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 4 | 100% |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 8 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 2 | 25% |
| Librarian | 1 | 13% |
| Student > Postgraduate | 1 | 13% |
| Student > Master | 1 | 13% |
| Unknown | 3 | 38% |
| Readers by discipline | Count | As % |
|---|---|---|
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| Computer Science | 2 | 25% |
| Neuroscience | 1 | 13% |
| Unknown | 3 | 38% |